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Stock-Based Compensation Expense (Detail) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Share Based Compensation	$ 10,439	$ 5,189	$ 2,410
Employee and Director Stock-Based Compensation Expense
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Share Based Compensation	10,439	5,185	2,378
Non-Employees Stock-Based Compensation Expense
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Share Based Compensation		4	32
Research and Development Expense
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Share Based Compensation	3,514	2,103	632
General and Administrative Expense
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Share Based Compensation	$ 6,925	$ 3,086	$ 1,778

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- Definition

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

-Number 95

-Paragraph 28

-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.



Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 230

-SubTopic 10

-Section 45

-Paragraph 28

-Subparagraph (a)

-URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3602-108585

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