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Consolidated Statements Of Cash Flows (USD $)
In Thousands, unless otherwise specified
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Operating activities      
Net loss $ (69,949) $ (48,597) $ (57,308)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 1,207 1,303 1,415
Amortization of intangible assets   299 980
Loss (gain) on disposal of property and equipment 8 20 (36)
Accretion of discounts and amortization of premiums of marketable securities 1,298 1,172 367
Interest associated with long-term note payable to Holdings 2,190 1,871 1,597
Fair value adjustment of the warrant and contingent liabilities to Holdings, including the impact of the anti-dilution provision associated with the common stock and warrants issued to Symphony Capital Partners, L.P. and Symphony Strategic Partners, LLC (collectively, "Symphony")   (843) 8,816
Stock compensation expense 10,439 5,189 2,410
Changes in operating assets and liabilities:      
Accounts receivable 8,522 (8,526) (106)
Prepaid expenses and other current assets (922) 230 (774)
Restricted cash and other assets (116) (290) (38)
Accounts payable 126 (289) 643
Accrued liabilities and other long term liabilities 1,916 (2,167) 3,381
Deferred revenues 1,472 3,512 (12,717)
Net cash used in operating activities (43,809) (47,116) (51,370)
Investing activities      
Purchases of marketable securities (206,149) (111,205) (80,835)
Proceeds from maturities of marketable securities 169,387 77,729 30,750
Purchases of property and equipment, net (2,931) (1,142) (420)
Net cash used in investing activities (39,693) (34,618) (50,505)
Financing activities      
Proceeds from issuances of common stock and warrants, net of issuance costs 71,780 91,298 87,399
Proceeds from exercise of stock options and restricted stock awards 1,955 10 160
Proceeds from employee stock purchase plan 307 132 72
Payment of notes payable to Holdings (15,000)    
Net cash provided by financing activities 59,042 91,440 87,631
Effect of exchange rate on cash and cash equivalents 118 (218) (23)
Net increase (decrease) in cash and cash equivalents (24,342) 9,488 (14,267)
Cash and cash equivalents at beginning of year 31,941 22,453 36,720
Cash and cash equivalents at end of year 7,599 31,941 22,453
Non-cash investing and financing activities:      
Warrants issued in conjunction with the SDI transaction     6,638
Disposal of fully depreciated property and equipment 169 1,181 42
Net change in unrealized gain (loss) on marketable securities 48 14 (17)
Aspire Capital purchase agreement
      
Non-cash investing and financing activities:      
Shares issued     1,200
SDI transaction
      
Non-cash investing and financing activities:      
Shares issued     $ 1,551