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Stockholders' Equity (Tables)

3 Months Ended

Mar. 31, 2013

Option Activity under Stock-Based Compensation Plans

Option activity under our stock-based compensation plans during the three months ended March 31, 2013 was as follows (in thousands except per share amounts):

		Shares Underlying Outstanding Options				Weighted-Average Exercise Price Per Share				Weighted-Average Remaining Contractual Term (years)				Aggregate Intrinsic Value
Balance as of December 31, 2012			13,806			$	3.38
Options granted			2,981				2.96
Options exercised			(57	)			1.50
Options cancelled:
Options forfeited (unvested)			(361	)			3.64
Options cancelled (vested)			(21	)			2.85
Balance as of March 31 2013			16,348			$	3.31				7.18			$	2,086
Vested and expected to vest as of March 31, 2013			15,089			$	3.32				7.03			$	2,065
Exercisable as of March 31, 2013			8,625			$	3.41				5.88			$	1,814

Summary of Restricted Stock Units Activity

Restricted stock unit activity under our stock-based compensation plans during the three months ended March 31, 2013 was as follows (in thousands except per share amounts):

		Number of Shares				Weighted-Average Grant-Date  Fair Value
Balance as of December 31, 2012			1,755			$	4.23
Granted			—				—
Vested			—				—
Forfeited or expired			(30	)			4.22
Balance as of March 31, 2013			1,725			$	4.23

Fair Value-Based Measurements and Weighted-Average Assumptions

The fair value-based measurements and weighted-average assumptions used in the calculations of these measurements are as follows:

		Stock Options								Employee Stock Purchase Plan
		Three Months Ended March 31,								Three Months Ended March 31,
		2013				2012				2013				2012
Weighted-average fair value		$	2.70			$	3.27			$	1.46			$	3.15
Risk-free interest rate			1.1	%			0.5	%			0.2	%			0.2	%
Expected life (in years)			5.8				4.0				1.3				1.3
Volatility			1.4				1.6				0.7				1.6

Stock-Based Compensation Expense

The components of stock-based compensation expense were (in thousands):

		Three Months Ended March 31,
		2013				2012
Research and development		$	1,323			$	803
General and administrative			2,943				1,519
Total		$	4,266			$	2,322

X

- Definition

Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits.

+ References

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

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- Definition

Tabular disclosure of the following for fully vested share options (or share units) and share options expected to vest at the date of the latest statement of financial position: the number, weighted-average exercise price (or conversion ratio), aggregate intrinsic value (except for nonpublic entities), and weighted-average remaining contractual term of options (or share units) outstanding.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (e)(1)

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- Definition

Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

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