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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 3 Months Ended
Mar. 31, 2013
Mar. 31, 2012
Operating activities    
Net loss $ (20,825) $ (16,505)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 319 292
Accretion of discounts and amortization of premiums of marketable securities 280 304
Interest associated with long-term note payable to Holdings   547
Stock compensation expense 4,266 2,322
Changes in operating assets and liabilities:    
Accounts receivable (542) 8,152
Prepaid expenses and other current assets 835 (738)
Restricted cash and other assets 13 (83)
Accounts payable (439) 318
Accrued liabilities and other long term liabilities (1,905) (1,844)
Deferred revenues (888) (946)
Net cash used in operating activities (18,886) (8,181)
Investing activities    
Purchases of marketable securities (13,454) (32,836)
Proceeds from maturities of marketable securities 50,340 27,425
Purchases of property and equipment, net (535) (932)
Net cash provided by (used in) investing activities 36,351 (6,343)
Financing activities    
Proceeds from issuances of common stock and warrants, net of issuance costs (142) 1,054
Proceeds from exercise of stock options and restricted stock awards 10 1,071
Proceeds from employee stock purchase plan 147 128
Net cash provided by financing activities 15 2,253
Effect of exchange rate on cash and cash equivalents (63) 83
Net increase (decrease) in cash and cash equivalents 17,417 (12,188)
Cash and cash equivalents at beginning of year 7,599 31,941
Cash and cash equivalents at end of year 25,016 19,753
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 1 5
Net change in unrealized gain (loss) on marketable securities $ (8)