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Collaborative Research, Development, and License Agreements - Additional Information (Detail) (USD $) | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |  |  | 12 Months Ended |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |  | 1 Months Ended | 12 Months Ended | 3 Months Ended | 6 Months Ended |  |  |  |  |  | 1 Months Ended
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Dec. 31, 2008 Glaxo, Smith, Kline Project | Jun. 30, 2013 Glaxo, Smith, Kline | Jun. 30, 2012 Glaxo, Smith, Kline | Jun. 30, 2013 Glaxo, Smith, Kline | Jun. 30, 2012 Glaxo, Smith, Kline | Dec. 31, 2011 Glaxo, Smith, Kline | Dec. 31, 2012 Glaxo, Smith, Kline | Jun. 30, 2013 Glaxo, Smith, Kline Maximum | Dec. 31, 2011 Glaxo, Smith, Kline Expansion | Jun. 30, 2013 Glaxo, Smith, Kline Follow-On TLR 7/9 program and other TLR programs Maximum | Jun. 30, 2013 Glaxo, Smith, Kline Annual net sales milestones achieved Maximum | Sep. 30, 2006 Astra Zeneca | Jun. 30, 2013 Astra Zeneca | Jun. 30, 2012 Astra Zeneca | Jun. 30, 2013 Astra Zeneca | Jun. 30, 2012 Astra Zeneca | Dec. 31, 2008 Astra Zeneca | Dec. 31, 2012 Astra Zeneca | Oct. 31, 2011 Amendment | Dec. 31, 2011 Amendment | Dec. 31, 2012 Amendment Advance the program following completion of Phase 2a | Mar. 31, 2012 Amendment Advance the program following completion of Phase 2a | Jun. 30, 2013 Amendment Advance the program following completion of Phase 2a | Jun. 30, 2013 Amendment Advance the program following completion of Phase 2a Maximum | Jun. 30, 2012 National Institutes of Health Autoimmune Disease | May 31, 2012 National Institutes of Health Rheumatoid Arthiritis | Jul. 31, 2011 National Institutes of Health Skin Autoimmune Inflammation | Aug. 31, 2010 National Institutes of Health HBV | Jul. 31, 2010 National Institutes of Health HPV | Sep. 30, 2008 National Institutes of Health ISS Technology
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of programs for research and early clinical development | 4 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment |  |  |  |  |  |  |  | $ 125,000,000 |  | $ 12,000,000 | $ 60,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration Revenue | 10,000,000 | 357,000 | 357,000 | 714,000 | 714,000 |  |  |  |  |  |  | 10,000,000 | 180,000 | 180,000 | 360,000 | 360,000 |  |  | 3,000,000 |  | 6,000,000 | 2,600,000 |  |  |  |  |  |  |  |
Revenue from milestone payment |  |  |  |  |  | 12,000,000 |  |  | 3,000,000 |  |  |  | 819,000 | 1,086,000 | 1,165,000 | 1,478,000 | 4,500,000 |  |  |  |  |  | 20,000,000 | 100,000,000 |  |  |  |  |  |
Deferred revenue recognition period |  | 7 years |  | 7 years |  |  |  |  |  |  |  |  | 50 months |  | 50 months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  | 3,500,000 |  | 3,500,000 |  |  | 4,200,000 |  |  |  |  |  | 6,500,000 |  | 6,500,000 |  |  | 7,700,000 |  |  |  |  |  |  |  |  |  |  |  |
Research collaboration and license agreement period |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of clinical development activities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  |  |  |  |  |  |  |  |
Grants receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 600,000 | 400,000 | 600,000 | 1,100,000 | 600,000 |
Contract agreement period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years
Contract awarded to develop technology |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 17,000,000

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- Definition The costs incurred in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, excluding in-process research and development acquired in a business combination consummated during the period. Excludes software research and development, which has a separate concept. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Research and Development -URI http://asc.fasb.org/extlink&oid=6523717 + Details
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