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Stockholders' Equity (Tables)

6 Months Ended

Jun. 30, 2013

Option Activity under Stock-Based Compensation Plans

10,000,000.Option activity under our stock-based compensation plans during the six months ended June 30, 2013 was as follows (in thousands except per share amounts):

		Shares Underlying Outstanding Options				Weighted-Average Exercise Price Per  Share				Weighted-Average Remaining Contractual Term (years)				Aggregate Intrinsic Value
Balance as of December 31, 2012			13,806			$	3.38
Options granted			5,421				2.74
Options exercised			(74	)			1.41
Options cancelled:
Options forfeited (unvested)			(1,350	)			3.32
Options cancelled (vested)			(181	)			4.09
Balance as of June 30, 2013			17,622			$	3.19				6.27			$	263
Vested and expected to vest as of June 30, 2013			16,754			$	3.20				6.12			$	263
Exercisable as of June 30, 2013			10,503			$	3.37				4.46			$	263

Summary of Restricted Stock Units Activity

Restricted stock unit activity under our stock-based compensation plans during the six months ended June 30, 2013 was as follows (in thousands except per share amounts):

		Number of Shares				Weighted-Average Grant-Date  Fair Value
Balance as of December 31, 2012			1,755			$	4.23
Granted			—				—
Vested			—				—
Forfeited or expired			(95	)			4.25
Balance as of June 30, 2013			1,660			$	4.23

Fair Value-Based Measurements and Weighted-Average Assumptions

The fair value-based measurements and weighted-average assumptions used in the calculations of these measurements are as follows:

		Stock Options								Stock Options								Employee Stock Purchase Plan
		Three Months Ended June 30,								Six Months Ended June 30,								Six Months Ended June 30,
		2013				2012				2013				2012				2013				2012
Weighted-average fair value		$	2.05			$	3.34			$	2.46			$	3.30			$	1.46			$	3.80
Risk-free interest rate			0.9	%			0.6	%			1.0	%			0.5	%			0.2	%			0.2	%
Expected life (in years)			6.0				4.0				5.9				4.0				1.3				1.0
Volatility			1.4				1.6				1.4				1.6				0.7				1.6

Stock-Based Compensation Expense

The components of stock-based compensation expense were (in thousands):

		Three Months Ended June 30,								Six Months Ended June 30,
		2013				2012				2013				2012
Research and development		$	1,027			$	938			$	2,350			$	1,741
General and administrative			2,709				1,131				5,652				2,650
Total		$	3,736			$	2,069			$	8,002			$	4,391

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- Definition

Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits.

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- Definition

Tabular disclosure of the following for fully vested share options (or share units) and share options expected to vest at the date of the latest statement of financial position: the number, weighted-average exercise price (or conversion ratio), aggregate intrinsic value (except for nonpublic entities), and weighted-average remaining contractual term of options (or share units) outstanding.

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Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

+ References

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