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Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2013

Option Activity under Stock-Based Compensation Plans

Option activity under our stock-based compensation plans during the nine months ended September 30, 2013 was as follows (in thousands except per share amounts):

	Shares Underlying Outstanding Options								Weighted-Average Exercise Price Per Share								Weighted-Average Remaining Contractual Term (years)								Aggregate Intrinsic Value
Balance as of December 31, 2012		13,806					$				3.38
Options granted		5,542									2.71
Options exercised		(74	)								1.41
Options cancelled:
Options forfeited (unvested)		(2,028	)								3.33
Options cancelled (vested)		(381	)								3.56
Balance as of September 30, 2013		16,865					$				3.17							5.35					$				310
Vested and expected to vest as of September 30, 2013		16,272					$				3.18							4.97					$				310
Exercisable as of September 30, 2013		10,977					$				3.35							3.37					$				307

Summary of Restricted Stock Units Activity

Restricted stock unit activity under our stock-based compensation plans during the nine months ended September 30, 2013 was as follows (in thousands except per share amounts):

	Number of Shares				Weighted-Average Grant-Date Fair Value
Balance as of December 31, 2012		1,755			$		4.23
Granted		250					1.23
Vested		—					—
Forfeited or expired		(230	)				4.23
Balance as of September 30, 2013		1,775			$		3.81

Fair Value-Based Measurements and Weighted-Average Assumptions

The fair value-based measurements and weighted-average assumptions used in the calculations of these measurements are as follows:

	Stock Options												Stock Options												Employee Stock Purchase Plan
	Three Months Ended September 30,												Nine Months Ended September 30,												Nine Months Ended September 30,
	2013						2012						2013						2012						2013						2012
Weighted-average fair value	$		1.15				$		3.34				$		2.43				$		3.30				$		0.93				$		3.80
Risk-free interest rate			1.9		%				0.6		%				1.1		%				0.5		%				0.2		%				0.2			%
Expected life (in years)			5.6						4.0						5.9						4.0						1.3						1.0
Volatility			1.5						1.6						1.4						1.6						0.8						1.6

Stock-Based Compensation Expense

The components of stock-based compensation expense were (in thousands):

	Three Months Ended September 30,														Nine Months Ended September 30,
	2013					2012							2013							2012
Research and development	$		1,001			$		824					$				3,351			$		2,565
General and administrative			1,844					1,079									7,496					3,729
Total	$		2,845			$		1,903					$				10,847			$		6,294

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- Definition

Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits.

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- Definition

Tabular disclosure of the following for fully vested share options (or share units) and share options expected to vest at the date of the latest statement of financial position: the number, weighted-average exercise price (or conversion ratio), aggregate intrinsic value (except for nonpublic entities), and weighted-average remaining contractual term of options (or share units) outstanding.

+ References

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-Publisher FASB

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Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

+ References

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+ References

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