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Condensed Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended 9 Months Ended
Sep. 30, 2013
Sep. 30, 2012
Sep. 30, 2013
Sep. 30, 2012
Revenues:        
Collaboration revenue $ 1,110 $ 1,050 $ 3,349 $ 3,602
Grant revenue 1,700 1,219 3,855 3,188
Service and license revenue 117 605 1,200 1,118
Total 2,927 2,874 8,404 7,908
Operating expenses:        
Research and development 11,770 12,850 38,739 36,631
General and administrative 5,807 7,121 22,243 18,871
Unoccupied facility expense 918   918  
Total operating expenses 18,495 19,971 61,900 55,502
Loss from operations (15,568) (17,097) (53,496) (47,594)
Interest income 37 91 163 208
Interest expense (24) (589) (83) (1,765)
Other expense (120) (196) (248) (255)
Net loss $ (15,675) $ (17,791) $ (53,664) $ (49,406)
Basic and diluted net loss per share $ (0.09) $ (0.10) $ (0.29) $ (0.30)
Weighted-average shares used to compute basic and diluted net loss per share 183,022 177,870 182,960 167,039