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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 9 Months Ended
Sep. 30, 2013
Sep. 30, 2012
Operating activities    
Net loss $ (53,664) $ (49,406)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 986 898
Gain on disposal of property and equipment 4 6
Accretion of discounts and amortization of premiums of marketable securities 692 970
Interest associated with long-term note payable to Holdings   1,642
Unoccupied facility expense 918  
Stock compensation expense 10,847 6,294
Changes in operating assets and liabilities:    
Accounts receivable (1,154) 5,842
Prepaid expenses and other current assets 932 (1,289)
Restricted cash and other assets 166 (74)
Accounts payable (877) (462)
Accrued liabilities and other long term liabilities (2,489) 1,011
Deferred revenues (3,191) (1,649)
Net cash used in operating activities (46,830) (36,217)
Investing activities    
Purchases of marketable securities (48,573) (169,634)
Proceeds from maturities of marketable securities 101,105 127,085
Purchases of property and equipment, net (1,316) (1,727)
Net cash provided by (used in) investing activities 51,216 (44,276)
Financing activities    
Payments and proceeds from issuances of common stock and warrants, net of issuance costs (143) 71,124
Proceeds from exercise of stock options and restricted stock awards 30 1,789
Proceeds from employee stock purchase plan 224 307
Net cash provided by financing activities 111 73,220
Effect of exchange rate on cash and cash equivalents 95 (18)
Net increase (decrease) in cash and cash equivalents 4,592 (7,291)
Cash and cash equivalents at beginning of year 7,599 31,941
Cash and cash equivalents at end of year 12,191 24,650
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 8 29
Net change in unrealized gain on marketable securities $ (23) $ 32