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Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Revenues:      
Collaboration revenue $ 4,929 $ 4,610 $ 17,190
Grant revenue 5,138 3,939 3,110
Service and license revenue 1,184 1,165 1,314
Total revenues 11,251 9,714 21,614
Operating expenses:      
Research and development 50,870 49,146 51,322
General and administrative 25,943 28,164 17,570
Unoccupied facility expense 926    
Amortization of intangible assets 0 0 299
Total operating expenses 77,739 77,310 69,191
Loss from operations (66,488) (67,596) (47,577)
Other income (expense):      
Interest income 116 291 103
Interest expense   (2,351) (1,957)
Other income (expense) (348) (293) 834
Net loss (66,720) (69,949) (48,597)
Preferred stock deemed dividend (8,469)    
Net loss allocable to common stockholders $ (75,189) $ (69,949) $ (48,597)
Net loss per share allocable to common stockholders - basic and diluted $ (0.38) $ (0.41) $ (0.39)
Weighted average shares outstanding used to compute basic and diluted net loss per share allocable to common stockholders 196,275 170,469 125,101