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Stock-Based Compensation Expense (Detail) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]
Stock compensation expense	$ 12,340	$ 10,439	$ 5,189
Employees And Directors
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]
Stock compensation expense	11,828	10,439	5,185
Non Employee
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]
Stock compensation expense	512		4
Research and Development Expense
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]
Stock compensation expense	4,228	3,514	2,103
General and Administrative Expense
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items]
Stock compensation expense	$ 8,112	$ 6,925	$ 3,086