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Consolidated Statements Of Cash Flows (USD $)
In Thousands, unless otherwise specified
 12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Operating activities      
Net loss $ (66,720) $ (69,949) $ (48,597)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 1,327 1,207 1,303
Amortization of intangible assets 0 0 299
Loss (gain) on disposal of property and equipment 18 8 20
Accretion of discounts and amortization of premiums of marketable securities 923 1,298 1,172
Interest associated with long-term note payable to Symphony Dynamo Holdings LLC (“Holdings)   2,190 1,871
Fair value adjustment of the warrant and contingent liabilities to Holdings, including the impact of the anti-dilution provision associated with the common stock and warrants issued to Symphony Capital Partners, L.P. and Symphony Strategic Partners, LLC (collectively, "Symphony")     (843)
Unoccupied facility expense 926    
Stock compensation expense 12,340 10,439 5,189
Changes in operating assets and liabilities:      
Accounts receivable (622) 8,522 (8,526)
Prepaid expenses and other current assets 677 (922) 230
Restricted cash and other assets 176 (116) (290)
Accounts payable (657) 126 (289)
Accrued liabilities and other long term liabilities (2,291) 1,916 (2,167)
Deferred revenues (4,770) 1,472 3,512
Net cash used in operating activities (58,673) (43,809) (47,116)
Investing activities      
Purchases of marketable securities (192,044) (206,149) (111,205)
Proceeds from maturities of marketable securities 142,321 169,387 77,729
Purchases of property and equipment, net (1,629) (2,931) (1,142)
Net cash used in investing activities (51,352) (39,693) (34,618)
Financing activities      
Proceeds from issuances of common stock 80,856 71,780 91,298
Proceeds from issuances of preferred stock 44,209    
Proceeds from issuances of warrants         
Proceeds from exercise of stock options and restricted stock awards 112 1,955 10
Proceeds from employee stock purchase plan 224 307 132
Payment of notes payable to Holdings   (15,000)  
Net cash provided by financing activities 125,401 59,042 91,440
Effect of exchange rate changes on cash and cash equivalents 147 118 (218)
Net increase (decrease) in cash and cash equivalents 15,523 (24,342) 9,488
Cash and cash equivalents at beginning of year 7,599 31,941 22,453
Cash and cash equivalents at end of year 23,122 7,599 31,941
Non-cash investing and financing activities:      
Disposal of fully depreciated property and equipment 86 169 1,181
Net change in unrealized (loss) gain on marketable securities $ (76) $ 48 $ 14