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Collaborative Research and Development Agreements - Additional Information (Detail) (USD $) | 12 Months Ended | 1 Months Ended | 3 Months Ended | 12 Months Ended |  |  | 1 Months Ended | 3 Months Ended |  |  | 1 Months Ended | 12 Months Ended | 3 Months Ended |  |  |  |  |  | 1 Months Ended
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Dec. 31, 2011 | Dec. 31, 2008 Glaxo, Smith, Kline Project | Mar. 31, 2014 Glaxo, Smith, Kline | Dec. 31, 2013 Glaxo, Smith, Kline | Mar. 31, 2013 Glaxo, Smith, Kline | Dec. 31, 2011 Glaxo, Smith, Kline Expansion | Mar. 31, 2014 Glaxo, Smith, Kline Maximum | Mar. 31, 2014 Glaxo, Smith, Kline Maximum Annual net sales milestones achieved | Dec. 31, 2013 Glaxo, Smith, Kline Minimum | Sep. 30, 2006 Astra Zeneca | Mar. 31, 2014 Astra Zeneca | Mar. 31, 2013 Astra Zeneca | Dec. 31, 2013 Astra Zeneca | Oct. 31, 2011 Astra Zeneca | Oct. 31, 2011 Amendment | Dec. 31, 2011 Amendment | Mar. 31, 2014 Amendment Advance the program following completion of Phase 2a | Dec. 31, 2012 Amendment Advance the program following completion of Phase 2a | Mar. 31, 2012 Amendment Advance the program following completion of Phase 2a | Mar. 31, 2014 Amendment Maximum Advance the program following completion of Phase 2a | Sep. 30, 2013 Hepatic Fibrosis and Cirrhosis National Institutes of Health | Jun. 30, 2012 Autoimmune Disease National Institutes of Health | May 31, 2012 Rheumatoid Arthritis National Institutes of Health | Jul. 31, 2011 Skin Autoimmune Inflammation National Institutes of Health | Aug. 31, 2010 HBV National Institute Of Allergy And Infectious Diseases | Sep. 30, 2008 ISS Technology National Institute Of Allergy And Infectious Diseases
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of programs for research and early clinical development |  | 4 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment |  |  |  |  |  |  | $ 125,000,000 | $ 60,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration Revenue |  | 10,000,000 | 631,000 |  | 357,000 |  |  |  |  |  | 180,000 | 180,000 |  |  | 3,000,000 |  | 5,400,000 | 6,000,000 | 2,600,000 |  |  |  |  |  |  |
Revenue from milestone payment | 12,000,000 |  |  |  |  | 3,000,000 |  |  |  |  | 887,000 | 346,000 |  |  |  |  |  |  |  | 100,000,000 |  |  |  |  |  |
Deferred revenue recognition period |  |  |  |  |  |  | 7 years |  | 6 years |  | 24 months |  |  | 50 months |  |  |  |  |  |  |  |  |  |  |  |
Additional revenue recognized |  |  | 300,000 | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  | 1,900,000 | 2,500,000 |  |  |  |  |  |  | 8,400,000 |  | 4,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Research collaboration and license agreement period |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of clinical development activities |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 20,000,000 |  |  |  |  |  |  |  |  |  |
Grants receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000 | 600,000 | 400,000 | 600,000 | 1,400,000 |
Contract agreement period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years
Contract awarded to develop technology |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 17,000,000

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- Definition The costs incurred in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, excluding in-process research and development acquired in a business combination consummated during the period. Excludes software research and development, which has a separate concept. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Research and Development -URI http://asc.fasb.org/extlink&oid=6523717 + Details
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