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Stock-Based Compensation Expense (Detail) (USD $) In Thousands, unless otherwise specified | 3 Months Ended
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Mar. 31, 2014 | Mar. 31, 2013
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |
Stock-based compensation expense | $ 1,270 | $ 4,266
Research and Development Expense |  |
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |
Stock-based compensation expense | 692 | 1,323
General and Administrative Expense |  |
Deferred Compensation Arrangement With Individual Share Based Payments [Line Items] |  |
Stock-based compensation expense | $ 578 | $ 2,943

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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585 + Details
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