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Summary of Revenue Recognized under Agreement with GSK (Detail) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 12 Months Ended 3 Months Ended 1 Months Ended 3 Months Ended
Mar. 31, 2014
Mar. 31, 2013
Dec. 31, 2011
Mar. 31, 2014
National Institutes of Health
Mar. 31, 2013
National Institutes of Health
Dec. 31, 2008
Glaxo, Smith, Kline
Mar. 31, 2014
Glaxo, Smith, Kline
Mar. 31, 2013
Glaxo, Smith, Kline
Mar. 31, 2014
Astra Zeneca
Mar. 31, 2013
Astra Zeneca
Mar. 31, 2014
National Institute Of Allergy And Infectious Diseases
Mar. 31, 2013
National Institute Of Allergy And Infectious Diseases
Product Information [Line Items]                        
Initial payment           $ 10,000 $ 631 $ 357 $ 180 $ 180    
Subsequent payment                 675      
Milestone revenue     12,000           887 346    
Total revenues 3,498 2,085         631 357 1,742 526    
Grant revenue $ 1,125 $ 760   $ 251 $ 162           $ 874 $ 598