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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2014
Mar. 31, 2013
Operating activities    
Net loss $ (13,840) $ (20,825)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 339 319
Gain on disposal of property and equipment (20)  
Accretion of discounts and amortization of premiums of marketable securities 264 280
Unoccupied facility expense 77  
Stock-based compensation expense 1,270 4,266
Changes in operating assets and liabilities:    
Accounts receivable (103) (542)
Prepaid expenses and other current assets (948) 835
Restricted cash and other assets 266 13
Accounts payable 154 (439)
Accrued liabilities and other long term liabilities (1,671) (1,905)
Deferred revenues 3,036 (888)
Net cash used in operating activities (11,176) (18,886)
Investing activities    
Purchases of marketable securities (13,819) (13,454)
Proceeds from maturities of marketable securities 28,949 50,340
Purchases of property and equipment, net of proceeds from asset disposals (398) (535)
Net cash provided by investing activities 14,732 36,351
Financing activities    
Proceeds from issuances of common stock and warrants, net of issuance costs   (142)
Proceeds from exercise of stock options and restricted stock awards   10
Proceeds from employee stock purchase plan 69 147
Net cash provided by financing activities 69 15
Effect of exchange rate changes on cash and cash equivalents 3 (63)
Net increase in cash and cash equivalents 3,628 17,417
Cash and cash equivalents at beginning of period 23,122 7,599
Cash and cash equivalents at end of period 26,750 25,016
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 274 1
Net change in unrealized gain (loss) on marketable securities $ 69 $ (8)