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Collaborative Research and Development Agreements - Additional Information (Detail) (USD $) | 12 Months Ended | 1 Months Ended | 3 Months Ended | 6 Months Ended | 1 Months Ended | 3 Months Ended | 6 Months Ended |  | 12 Months Ended | 6 Months Ended |  | 12 Months Ended | 1 Months Ended | 3 Months Ended | 6 Months Ended |  |  |  |  |  |  | 1 Months Ended
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Dec. 31, 2011 | Oct. 31, 2011 Amendment | Mar. 31, 2014 Amendment Advance the program following completion of Phase 2a | Dec. 31, 2012 Amendment Advance the program following completion of Phase 2a | Mar. 31, 2012 Amendment Advance the program following completion of Phase 2a | Jun. 30, 2014 Maximum Amendment Advance the program following completion of Phase 2a | Dec. 31, 2008 Glaxo, Smith, Kline Project | Jun. 30, 2014 Glaxo, Smith, Kline | Mar. 31, 2014 Glaxo, Smith, Kline | Jun. 30, 2013 Glaxo, Smith, Kline | Jun. 30, 2014 Glaxo, Smith, Kline | Jun. 30, 2013 Glaxo, Smith, Kline | Dec. 31, 2013 Glaxo, Smith, Kline | Dec. 31, 2011 Glaxo, Smith, Kline Expansion | Jun. 30, 2014 Glaxo, Smith, Kline Maximum | Jun. 30, 2014 Glaxo, Smith, Kline Maximum Annual net sales milestones achieved | Dec. 31, 2013 Glaxo, Smith, Kline Minimum | Oct. 31, 2011 Astra Zeneca | Sep. 30, 2006 Astra Zeneca | Jun. 30, 2014 Astra Zeneca | Jun. 30, 2013 Astra Zeneca | Jun. 30, 2014 Astra Zeneca | Jun. 30, 2013 Astra Zeneca | Dec. 31, 2013 Astra Zeneca | Sep. 30, 2013 National Institutes of Health Hepatic Fibrosis and Cirrhosis | Jun. 30, 2012 National Institutes of Health Autoimmune Disease | May 31, 2012 National Institutes of Health Rheumatoid Arthritis | Jul. 31, 2011 National Institutes of Health Skin Autoimmune Inflammation | Aug. 31, 2010 National Institute Of Allergy And Infectious Diseases HBV | Sep. 30, 2008 National Institute Of Allergy And Infectious Diseases ISS Technology
Product Information [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of programs for research and early clinical development |  |  |  |  |  |  | 4 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential milestone payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 125,000,000 | $ 60,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaboration Revenue |  | 3,000,000 | 5,400,000 | 6,000,000 | 2,600,000 |  | 10,000,000 | 631,000 |  | 357,000 | 1,262,000 | 714,000 |  |  |  |  |  |  |  | 180,000 | 180,000 | 360,000 | 360,000 |  |  |  |  |  |  |
Revenue from milestone payment | 12,000,000 |  |  |  |  | 100,000,000 |  |  |  |  |  |  |  | 3,000,000 |  |  |  |  |  | 545,000 | 819,000 | 1,432,000 | 1,165,000 |  |  |  |  |  |  |
Deferred revenue recognition period |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7 years |  | 6 years | 50 months |  |  |  | 24 months |  |  |  |  |  |  |  |
Additional revenue recognized |  |  |  |  |  |  |  | 300,000 | 300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  | 1,300,000 |  |  | 1,300,000 |  | 2,500,000 |  |  |  |  |  |  | 7,000,000 |  | 7,000,000 |  | 4,800,000 |  |  |  |  |  |
Research collaboration and license agreement period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3 years |  |  |  |  |  |  |  |  |  |  |
Grants receivable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 200,000 | 600,000 | 400,000 | 600,000 | 1,400,000 |
Contract agreement period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5 years
Contract awarded to develop technology |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 17,000,000

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