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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Operating activities    
Net loss $ (38,617) $ (37,989)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 680 646
(Loss) gain on disposal of property and equipment (24) 4
Accretion of discounts and amortization of premiums of marketable securities 500 530
Unoccupied facility expense 255  
Stock-based compensation expense 2,946 8,002
Changes in operating assets and liabilities:    
Accounts receivable 335 (1,020)
Prepaid expenses and other current assets (3,603) 811
Restricted cash and other assets (579) 14
Accounts payable 112 (913)
Accrued liabilities and other long term liabilities 3,217 (2,758)
Deferred revenues 996 (1,902)
Net cash used in operating activities (33,782) (34,575)
Investing activities    
Purchases of marketable securities (37,251) (29,527)
Proceeds from maturities of marketable securities 65,794 74,911
Purchases of property and equipment, net of proceeds from asset disposals (919) (828)
Net cash provided by investing activities 27,624 44,556
Financing activities    
Payment of issuance costs   (142)
Proceeds from exercise of stock options and restricted stock awards 13 30
Proceeds from employee stock purchase plan 70 147
Net cash provided by financing activities 83 35
Effect of exchange rate changes on cash and cash equivalents (15) (30)
Net (decrease) increase in cash and cash equivalents (6,090) 9,986
Cash and cash equivalents at beginning of period 23,122 7,599
Cash and cash equivalents at end of period 17,032 17,585
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 664 8
Net change in unrealized gain (loss) on marketable securities $ 70 $ (41)