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Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2014

Share Based Compensation [Abstract]

Option Activity under Stock-Based Compensation Plans

Option activity under our stock-based compensation plans during the nine months ended September 30, 2014 was as follows (in thousands except per share amounts):

		Shares Underlying  Outstanding Options (in thousands)				Weighted-Average Exercise Price Per Share				Weighted-Average Remaining Contractual Term (years)				Aggregate Intrinsic Value (in thousands)
Balance at December 31, 2013			15,765			$	3.17
Options granted			5,673				1.68
Options exercised			(25	)			0.54
Options cancelled:
Options forfeited (unvested)			(582	)			2.69
Options cancelled (vested)			(2,012	)			2.90
Balance at September 30, 2014			18,819				2.77				6.22			$	444
Vested and expected to vest at September 30, 2014			18,819				2.77				6.22			$	444
Exercisable at September 30, 2014			10,553				3.34				4.06			$	421

Summary of Restricted Stock Units Activity

Restricted stock unit activity under our stock-based compensation plans during the nine months ended September 30, 2014 was as follows (in thousands except per share amounts):

	Number of Shares (In thousands)				Weighted-Average Grant-Date Fair Value
Non-vested as of December 31, 2013		1,275			$	3.93
Granted		1,555			$	1.79
Vested		-			$	-
Forfeited or expired		(1,040	)		$	4.20
Non-vested as of September 30, 2014		1,790			$	1.91

Fair Value-Based Measurements and Weighted-Average Assumptions

The fair value-based measurements and weighted-average assumptions used in the calculations of these measurements are as follows:

		Stock Options								Stock Options								Employee Stock Purchase Plan
		Three Months Ended								Nine Months Ended								Nine Months Ended
		September 30,								September 30,								September 30,
		2014				2013				2014				2013				2014				2013
Weighted-average fair value		$	1.01			$	1.15			$	1.52			$	2.43			$	0.74			$	0.93
Risk-free interest rate			1.9	%			1.9	%			1.8	%			1.1	%			0.2	%			0.2	%
Expected life (in years)			5.5				5.6				5.9				5.9				1.2				1.3
Volatility			0.8				1.5				1.4				1.4				0.9				0.8

Stock-Based Compensation Expense

The components of stock-based compensation expense were (in thousands):

		Three Months Ended								Nine Months Ended
		September 30,								September 30,
		2014				2013				2014				2013
Research and development		$	731			$	1,001			$	2,161			$	3,351
General and administrative			855				1,844				2,371				7,496
Total		$	1,586			$	2,845			$	4,532			$	10,847

X

- Definition

Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits.

+ References

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (h)(1)

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- Definition

Tabular disclosure of the following for fully vested share options (or share units) and share options expected to vest at the date of the latest statement of financial position: the number, weighted-average exercise price (or conversion ratio), aggregate intrinsic value (except for nonpublic entities), and weighted-average remaining contractual term of options (or share units) outstanding.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (e)(1)

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- Definition

Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

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-Paragraph 2

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

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-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

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