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Collaborative Research and Development Agreements - Additional Information (Detail) (USD $)
1 Months Ended 12 Months Ended 1 Months Ended 3 Months Ended 9 Months Ended 1 Months Ended 3 Months Ended 9 Months Ended 9 Months Ended 12 Months Ended 1 Months Ended 3 Months Ended 9 Months Ended 1 Months Ended
Aug. 31, 2014
Dec. 31, 2011
Oct. 31, 2011
Amendment
Mar. 31, 2014
Amendment
Advance the program following completion of Phase 2a
Dec. 31, 2012
Amendment
Advance the program following completion of Phase 2a
Mar. 31, 2012
Amendment
Advance the program following completion of Phase 2a
Sep. 30, 2014
Maximum
Amendment
Advance the program following completion of Phase 2a
Dec. 31, 2008
Glaxo, Smith, Kline
Sep. 30, 2014
Glaxo, Smith, Kline
Jun. 30, 2014
Glaxo, Smith, Kline
Mar. 31, 2014
Glaxo, Smith, Kline
Sep. 30, 2013
Glaxo, Smith, Kline
Sep. 30, 2014
Glaxo, Smith, Kline
Sep. 30, 2013
Glaxo, Smith, Kline
Dec. 31, 2013
Glaxo, Smith, Kline
Sep. 30, 2014
Glaxo, Smith, Kline
Maximum
Dec. 31, 2013
Glaxo, Smith, Kline
Minimum
Dec. 31, 2011
Glaxo, Smith, Kline
Expansion
Oct. 31, 2011
Astra Zeneca
Sep. 30, 2006
Astra Zeneca
Sep. 30, 2014
Astra Zeneca
Sep. 30, 2013
Astra Zeneca
Sep. 30, 2014
Astra Zeneca
Sep. 30, 2013
Astra Zeneca
Dec. 31, 2013
Astra Zeneca
Aug. 31, 2014
National Institutes of Health
Sep. 30, 2013
National Institutes of Health
Hepatic Fibrosis and Cirrhosis
Jun. 30, 2012
National Institutes of Health
Autoimmune Disease
May 31, 2012
National Institutes of Health
Rheumatoid Arthritis
Jul. 31, 2011
National Institutes of Health
Skin Autoimmune Inflammation
Aug. 31, 2010
National Institute Of Allergy And Infectious Diseases
HBV
Sep. 30, 2008
National Institute Of Allergy And Infectious Diseases
ISS Technology
Product Information [Line Items]                                                                
Collaboration Revenue     $ 3,000,000 $ 5,400,000 $ 6,000,000 $ 2,600,000   $ 10,000,000 $ 631,000     $ 357,000 $ 1,893,000 $ 1,071,000             $ 180,000 $ 180,000 $ 540,000 $ 540,000                
Revenue from milestone payment   12,000,000         100,000,000                     3,000,000     309,000 573,000 1,741,000 1,738,000                
Deferred revenue recognition period                               7 years 6 years   50 months       24 months                  
Additional revenue recognized                 300,000 300,000 300,000                                          
Deferred revenue                 600,000       600,000   2,500,000           5,900,000   5,900,000   4,800,000              
Research collaboration and license agreement period                                       3 years                        
Number of healthy workers placeebo was delivered by inhalation 45                                                              
Description of doses well tolerated 15.4 mg/week                                                              
Grants receivable                                                   200,000 200,000 600,000 400,000 600,000 1,400,000  
Contract agreement period                                                               5 years
Contract awarded to develop technology                                                               $ 17,000,000