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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 9 Months Ended
Sep. 30, 2014
Sep. 30, 2013
Operating activities    
Net loss $ (68,436) $ (53,664)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,016 986
(Loss) gain on disposal of property and equipment (24) 4
Accretion of discounts and amortization of premiums of marketable securities 714 692
Unoccupied facility expense 386 918
Stock-based compensation expense 4,532 10,847
Changes in operating assets and liabilities:    
Accounts receivable 900 (1,154)
Prepaid expenses and other current assets (2,203) 932
Restricted cash and other assets (575) 166
Accounts payable 3,284 (877)
Accrued liabilities and other long term liabilities 4,334 (2,489)
Deferred revenues (799) (3,191)
Net cash used in operating activities (56,871) (46,830)
Investing activities    
Purchases of marketable securities (44,807) (48,573)
Proceeds from maturities of marketable securities 99,500 101,105
Purchases of property and equipment, net of proceeds from asset disposals (1,207) (1,316)
Net cash provided by investing activities 53,486 51,216
Financing activities    
Payment of issuance costs   (143)
Proceeds from exercise of stock options and restricted stock awards 13 30
Proceeds from employee stock purchase plan 130 224
Net cash provided by financing activities 143 111
Effect of exchange rate changes on cash and cash equivalents (224) 95
Net (decrease) increase in cash and cash equivalents (3,466) 4,592
Cash and cash equivalents at beginning of period 23,122 7,599
Cash and cash equivalents at end of period 19,656 12,191
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 675 8
Unrealized (loss) gain on marketable securities available-for-sale $ 69 $ (23)