<SEC-DOCUMENT>0001144204-14-009597.txt : 20140214
<SEC-HEADER>0001144204-14-009597.hdr.sgml : 20140214
<ACCEPTANCE-DATETIME>20140214150857
ACCESSION NUMBER:		0001144204-14-009597
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20140214
DATE AS OF CHANGE:		20140214
GROUP MEMBERS:		PETER KOLCHINSKY
GROUP MEMBERS:		RA CAPITAL HEALTHCARE FUND, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			DYNAVAX TECHNOLOGIES CORP
		CENTRAL INDEX KEY:			0001029142
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330728374
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-80035
		FILM NUMBER:		14615406

	BUSINESS ADDRESS:	
		STREET 1:		2929 SEVENTH STREET
		STREET 2:		SUITE 100
		CITY:			BERKELEY
		STATE:			CA
		ZIP:			94710
		BUSINESS PHONE:		5108485100

	MAIL ADDRESS:	
		STREET 1:		2929 SEVENTH STREET
		STREET 2:		SUITE 100
		CITY:			BERKELEY
		STATE:			CA
		ZIP:			94710

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RA CAPITAL MANAGEMENT, LLC
		CENTRAL INDEX KEY:			0001346824
		IRS NUMBER:				830406777
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-778-2500

	MAIL ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>v368869_sc13ga.htm
<DESCRIPTION>SCHEDULE 13G/A
<TEXT>
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SCHEDULE 13G</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Under the Securities Exchange Act of
1934</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in"><B>(Amendment No. 1)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; text-indent: 0in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><BR>
Dynavax Technologies Corporation</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Common Stock, $0.001 par value</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>268158102</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>December 31, 2013</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Date of Event Which Requires Filing of
this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box to designate the rule pursuant to
which this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif">
<tr>
    <TD STYLE="width: 2%; padding-bottom: 8pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 8pt; width: 4%">[ &nbsp; ]</td>
    <TD STYLE="padding-bottom: 8pt; width: 94%">Rule 13d-1(b)</td></tr>
<tr>
    <TD STYLE="padding-bottom: 8pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 8pt">[<b>X</b>]</td>
    <TD STYLE="padding-bottom: 8pt">Rule 13d-1(c)</td></tr>
<tr>
    <TD>&nbsp;</TD>
    <TD>[ &nbsp; ]</td>
    <TD>Rule 13d-1(d)</td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">*The remainder of this cover page shall be filled out for a
reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The information required in the remainder of this cover page
shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&ldquo;<B><I>Act</I></B>&rdquo;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<tr>
    <td colspan="4" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">CUSIP No. <b>268158102</b></font></td>
    <td style="padding: 1.45pt 3pt; font-size: 12pt; text-align: center"><font style="font-size: 12pt"><b>13G</b></font></td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Page <u>&nbsp;&nbsp;&nbsp;<b>2</b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u>&nbsp;of <u>&nbsp;&nbsp;&nbsp;<b>7</b>&nbsp;&nbsp;&nbsp;</u>&nbsp;Pages</font></td></tr>
<tr>
    <td colspan="6" style="padding: 1.45pt 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></td></tr>
<tr>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">1.</font></td>
    <TD COLSPAN="4" STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<br>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>RA Capital Management, LLC&#9;</b></P></td></tr>
<tr>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">2. </font></td>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</font></td></tr>
<tr>
    <td style="padding: 1.45pt 3pt 6pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt 6pt">&nbsp;</td>
    <td style="padding: 1.45pt 3pt 6pt"><font style="font-size: 10pt">(a)</font></td>
    <td colspan="3" style="padding-bottom: 6pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <td style="padding-bottom: 6pt">&nbsp;</td>
    <td style="padding-bottom: 6pt">&nbsp;</td>
    <TD STYLE="padding: 1.45pt 3pt 6pt"><font style="font-size: 10pt">(b)</font></td>
    <td colspan="3" style="padding-bottom: 6pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">3.</font></td>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">SEC Use Only </font></td></tr>
<tr>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">4.</font></td>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<font style="font-size: 10pt"><b>Massachusetts</b></font></td></tr>
<tr>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <td style="width: 4%"></td>
    <td style="width: 7%"></td>
    <td style="width: 6%"></td>
    <td style="width: 26%"></td>
    <td style="width: 22%"></td>
    <td style="width: 35%"></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <td rowspan="7" style="width: 18%; padding: 1.45pt 3pt"><font style="font-size: 10pt">Number of</font><br>
<font style="font-size: 10pt">Shares</font><br>
<font style="font-size: 10pt">Beneficially</font><br>
<font style="font-size: 10pt">Owned by</font><br>
<font style="font-size: 10pt">Each Reporting</font><br>
<font style="font-size: 10pt">Person With</font></td>
    <td style="width: 3%; padding: 1.45pt 3pt"><font style="font-size: 10pt">5.</font></td>
    <td style="width: 79%"><font style="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">6.</font></td>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>25,999,886 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">7.</font></td>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">8.</font></td>
    <TD STYLE="padding-top: 1.45pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>25,999,886 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <TD STYLE="width: 4%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="width: 7%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">9.</font></td>
    <TD STYLE="width: 89%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>25,999,886 shares</b></P></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">10.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </font><FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">11.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>9.9%</b></P></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">12.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>IA</b></P></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


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<tr>
    <td colspan="4" style="padding: 1.45pt 3pt"><font style="font-size: 10pt">CUSIP No. <b>268158102</b></font></td>
    <td style="padding: 1.45pt 3pt; font-size: 12pt; text-align: center"><font style="font-size: 12pt"><b>13G</b></font></td>
    <td style="padding: 1.45pt 3pt"><font style="font-size: 10pt">Page <u>&nbsp;&nbsp;&nbsp;<b>3</b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</u>&nbsp;of <u>&nbsp;&nbsp;&nbsp;<b>7</b>&nbsp;&nbsp;</u>&nbsp;Pages</font></td></tr>
<tr>
    <td colspan="6" style="padding: 1.45pt 3pt">&nbsp;</td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">1.</font></td>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<br>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>Peter Kolchinsky&#9;</b></P></td></tr>
<tr>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">2. </font></td>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</font></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">(a)</font></td>
    <TD COLSPAN="3" STYLE="padding-top: 3pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">(b)</font></td>
    <TD COLSPAN="3" STYLE="padding-top: 3pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></td></tr>
<tr>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">3.</font></td>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">SEC Use Only </font></td></tr>
<tr>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">4.</font></td>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</font>&nbsp;<b>United States</b></td></tr>
<tr>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <td style="width: 4%"></td>
    <td style="width: 7%"></td>
    <td style="width: 6%"></td>
    <td style="width: 26%"></td>
    <td style="width: 22%"></td>
    <td style="width: 35%"></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <TD ROWSPAN="7" STYLE="width: 18%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Number of</font><br>
<font style="font-size: 10pt">Shares</font><br>
<font style="font-size: 10pt">Beneficially</font><br>
<font style="font-size: 10pt">Owned by</font><br>
<font style="font-size: 10pt">Each Reporting</font><br>
<font style="font-size: 10pt">Person With</font></td>
    <TD STYLE="width: 3%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">5.</font></td>
    <TD STYLE="width: 79%; padding-top: 3pt"><font style="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">6.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>25,999,886 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">7.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>0 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">8.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<b>25,999,886 shares</b></font></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<table cellspacing="0" cellpadding="0" style="font: 10pt Times New Roman, Times, Serif; width: 100%">
<tr>
    <TD STYLE="width: 4%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="width: 7%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">9.</font></td>
    <TD STYLE="width: 89%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>25,999,886 shares</b></P></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">10.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><font style="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </font><FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">11.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>9.9%</b></P></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
<tr>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><font style="font-size: 10pt">12.</font></td>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><b>IN</b></P></td></tr>
<tr>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></td></tr>
</table>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD COLSPAN="4" STYLE="padding: 1.45pt 3pt"><FONT STYLE="font-size: 10pt">CUSIP No. </FONT>&nbsp;<FONT STYLE="font-size: 10pt"><B>268158102</B></FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt; font-size: 12pt; text-align: center"><FONT STYLE="font-size: 12pt"><B>13G</B></FONT></TD>
    <TD STYLE="padding: 1.45pt 3pt"><FONT STYLE="font-size: 10pt">Page <U>&nbsp;&nbsp;&nbsp;<B>4</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</U>&nbsp;of <U>&nbsp;&nbsp;&nbsp;<B>7</B>&nbsp;&nbsp;&nbsp;</U>&nbsp;Pages</FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="padding: 1.45pt 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">1.</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>RA Capital Healthcare Fund, L.P.&#9;</B></P></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">2. </FONT></TD>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="3" STYLE="padding-top: 3pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="3" STYLE="padding-top: 3pt"><FONT STYLE="font-family: Wingdings">&#168;</FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">SEC Use Only </FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
    <TD COLSPAN="4" STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT>&nbsp;<FONT STYLE="font-size: 10pt"><B>Delaware</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="6" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD ROWSPAN="7" STYLE="width: 18%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">Number of</FONT><BR>
<FONT STYLE="font-size: 10pt">Shares</FONT><BR>
<FONT STYLE="font-size: 10pt">Beneficially</FONT><BR>
<FONT STYLE="font-size: 10pt">Owned by</FONT><BR>
<FONT STYLE="font-size: 10pt">Each Reporting</FONT><BR>
<FONT STYLE="font-size: 10pt">Person With</FONT></TD>
    <TD STYLE="width: 3%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">5.</FONT></TD>
    <TD STYLE="width: 79%; padding-top: 3pt"><FONT STYLE="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>&nbsp;&nbsp;20,657,853 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;0 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt"><FONT STYLE="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>&nbsp;&nbsp;20,657,853 shares</B></FONT></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
<TR>
    <TD STYLE="width: 4%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 7%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
    <TD STYLE="width: 89%; padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>20,657,853 shares</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="font-size: 10pt; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount
        in Row (9) Excludes </FONT><FONT STYLE="font-family: Wingdings">&#168;</FONT></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Certain Shares (See Instructions)</P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="font-size: 10pt; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>7.9%</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="font-size: 10pt; border-bottom: Black 1.5pt solid"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
    <TD STYLE="padding-top: 3pt; padding-right: 3pt; padding-left: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><B>PN</B></P></TD></TR>
<TR>
    <TD COLSPAN="3" STYLE="border-bottom: Black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">CUSIP No. <B>268158102</B></FONT>&#9;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 1.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&#9;<B>Name of Issuer:</B> Dynavax Technologies Corporation
(the &ldquo;Issuer&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(b)&#9;<B>Address of the Issuer&rsquo;s Principal Executive
Offices:</B> 2929 Seventh Street, Suite 100, Berkeley, CA 94710-2753.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 2.&#9;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(a)&#9;<B>Name of Person Filing: </B> This
joint statement on Schedule 13G is being filed by Peter Kolchinsky, RA Capital Management, LLC (&ldquo;Capital&rdquo;), and RA
Capital Healthcare Fund, L.P. (the &ldquo;Fund&rdquo;). Mr. Kolchinsky, Capital and the Fund are collectively referred to herein
as the &ldquo;Reporting Persons.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(b)&#9;<B>Address of Principal Business Office:</B>
The principal business office of the Reporting Persons is c/o RA Capital Management, LLC, 20 Park Plaza, Suite 1200, Boston, MA
02116.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(c) &#9;<B>Citizenship:</B> Capital is a Massachusetts
limited liability company. The Fund is a Delaware limited partnership. Mr. Kolchinsky is a United States citizen.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(d)&#9;<B>Title and Class of Securities: </B>Common
stock (&ldquo;Common Stock&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">(e)&#9;<B>CUSIP Number:</B> 268158102</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 3.&#9;If this statement is filed pursuant to &sect;&sect;240.13d-1(b)
or 240.13d-2(b) or (c), check whether the person filing is a:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 4. &#9;Ownership:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Provide the following information regarding the aggregate number
and percentage of the class of securities of the issuer identified in Item 1.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; font-size: 10pt">(a)</TD>
    <TD STYLE="width: 94%; padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Amount Beneficially Owned:**</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC - 25,999,886
        shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 25,999,886 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P. - 20,657,853
        shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt; font-size: 10pt">(b)</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt; font-size: 10pt">Percent of Class:**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC &ndash; 9.9%</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky &ndash; 9.9%</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P. &ndash;
        7.9%</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">CUSIP No. <B>268158102</B></FONT>&#9;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt">(c)</TD>
    <TD COLSPAN="2" STYLE="padding-right: 2.7pt; padding-left: 2.7pt">Number of shares as to which such person has:</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; padding-bottom: 12pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="width: 6%; padding-right: 2.7pt; padding-left: 2.7pt">(i)</TD>
    <TD STYLE="width: 88%; padding-right: 2.7pt; padding-left: 2.7pt">sole power to vote or to direct the vote **</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P. - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">(ii)</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt">shared power to vote or to direct the vote**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC - 25,999,886
        shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 25,999,886 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P. - 20,657,853
        shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">(iii)</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt">Sole power to dispose or to direct the disposition of**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P. - 0 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">(iv)</TD>
    <TD STYLE="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">shared power to dispose or to direct the disposition of**</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-bottom: 12pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 2.7pt; padding-bottom: 12pt; padding-left: 2.7pt">&nbsp;</TD>
    <TD STYLE="padding-right: 2.7pt; padding-left: 2.7pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Management, LLC - 25,999,886
        shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Peter Kolchinsky - 25,999,886 shares</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RA Capital Healthcare Fund, L.P. - 20,657,853
        shares</P></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">** Shares reported herein for the Reporting Persons represent
shares of Common Stock beneficially owned as set forth below and additional shares of Common Stock issuable upon the conversion
of certain shares of Series B Convertible Preferred Stock (&ldquo;Series B Shares&rdquo;) beneficially owned as set forth below.
In the aggregate, the Reporting Persons own 43,430 Series B Shares convertible into 43,430,000 shares of Common Stock. The Series
B Shares may not be converted such that the number of shares of Common Stock held by the Reporting Persons and their affiliates
after such conversion exceeds 9.98% of the outstanding shares of Common Stock. Shares reported herein for the Fund represent shares
of Common Stock held of record by the Fund and additional shares of Common Stock issuable upon the conversion of certain Series
B Shares held of record by the Fund. Shares reported herein for Capital represent (a) the above-referenced shares of Common Stock
and additional shares of Common Stock issuable upon the conversion of certain Series B Shares as reported for the Fund, for which
the LLC serves as the sole general partner, and (b) shares of Common Stock held in a separately managed account for which Capital
serves as investment adviser, and additional shares of Common Stock issuable upon the conversion of certain Series B Shares held
in such managed account. Shares reported herein for Mr. Kolchinsky represent the above-referenced shares of Common Stock (including
additional shares of Common Stock issuable upon the exercise of certain Series B Shares) reported for Capital, for which Mr. Kolchinsky
serves as the manager. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the
extent of its or his pecuniary interest therein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 5.&#9;Ownership of Five Percent or Less of a Class:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">CUSIP No. <B>268158102</B></FONT>&#9;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in"><B>Item 6.&#9;Ownership of More than
Five Percent on Behalf of Another Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 7. &#9;Identification and Classification of the Subsidiary
Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 8.&#9;Identification and Classification of Members of
the Group:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 9.&#9;Notice of Dissolution of Group:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 10.&#9;Certification:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">By signing below I hereby certify that, to the best of my knowledge
and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing
or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant
in any transaction having that purpose or effect.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><U>Exhibits</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">1</TD><TD>Joint Filing Agreement by and among the Reporting Persons is incorporated herein by reference to Exhibit 1 to the Schedule
13G filed by the Reporting Persons with the Securities and Exchange Commission on November 5, 2013.</TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">CUSIP No. <B>268158102</B></FONT>&#9;</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURE</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">After reasonable inquiry and to the best
of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">Date: </FONT>February
14, 2014</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><BR>
RA CAPITAL MANAGEMENT, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">By: /s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Manager</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">PETER KOLCHINSKY</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">/s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">RA CAPITAL HEALTHCARE FUND, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">By: RA Capital Management, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in; text-indent: 0.5in">General Partner</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">By: /s/ Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">-------------------------------------------------</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Peter Kolchinsky</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">Manager</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3.5in"></P>

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