XML 64 R4.htm IDEA: XBRL DOCUMENT v2.4.1.9

Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Revenues:
Collaboration revenue	$ 7,933us-gaap_ContractsRevenue	$ 4,929us-gaap_ContractsRevenue	$ 4,610us-gaap_ContractsRevenue
Grant revenue	2,688us-gaap_RevenueFromGrants	5,138us-gaap_RevenueFromGrants	3,939us-gaap_RevenueFromGrants
Service and license revenue	411us-gaap_LicenseAndServicesRevenue	1,184us-gaap_LicenseAndServicesRevenue	1,165us-gaap_LicenseAndServicesRevenue
Total revenues	11,032us-gaap_Revenues	11,251us-gaap_Revenues	9,714us-gaap_Revenues
Operating expenses:
Research and development	84,580us-gaap_ResearchAndDevelopmentExpense	50,870us-gaap_ResearchAndDevelopmentExpense	49,146us-gaap_ResearchAndDevelopmentExpense
General and administrative	17,377us-gaap_GeneralAndAdministrativeExpense	25,943us-gaap_GeneralAndAdministrativeExpense	28,164us-gaap_GeneralAndAdministrativeExpense
Unoccupied Facility expense	386us-gaap_BusinessExitCosts1	926us-gaap_BusinessExitCosts1
Total operating expenses	102,343us-gaap_CostsAndExpenses	77,739us-gaap_CostsAndExpenses	77,310us-gaap_CostsAndExpenses
Loss from operations	(91,311)us-gaap_OperatingIncomeLoss	(66,488)us-gaap_OperatingIncomeLoss	(67,596)us-gaap_OperatingIncomeLoss
Other income (expense):
Interest income	191us-gaap_InvestmentIncomeInterest	116us-gaap_InvestmentIncomeInterest	291us-gaap_InvestmentIncomeInterest
Interest expense	(35)us-gaap_InterestExpense		(2,351)us-gaap_InterestExpense
Other income (expense), net	433us-gaap_OtherNonoperatingIncomeExpense	(348)us-gaap_OtherNonoperatingIncomeExpense	(293)us-gaap_OtherNonoperatingIncomeExpense
Net loss	(90,722)us-gaap_NetIncomeLoss	(66,720)us-gaap_NetIncomeLoss	(69,949)us-gaap_NetIncomeLoss
Preferred stock deemed dividend		(8,469)us-gaap_PreferredStockDividendsIncomeStatementImpact
Net loss allocable to common stockholders	$ (90,722)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (75,189)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic	$ (69,949)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic
Net loss per share allocable to common stockholders - basic and diluted	$ (3.45)us-gaap_EarningsPerShareBasicAndDiluted	$ (3.83)us-gaap_EarningsPerShareBasicAndDiluted	$ (4.10)us-gaap_EarningsPerShareBasicAndDiluted
Weighted average shares outstanding used to compute basic and diluted net loss per share allocable to common stockholders	26,289us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	19,628us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted	17,047us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted

X

- Definition

Amount of expenses associated with exit or disposal activities pursuant to an authorized plan. Includes, but is not limited to, one-time termination benefits, termination of an operating lease or other contract, consolidating or closing facilities, and relocating employees, and termination benefits associated with an ongoing benefit arrangement. Excludes expenses associated with special or contractual termination benefits, a discontinued operation or an asset retirement obligation.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 230



-SubTopic 10



-Section 45



-Paragraph 28



-Subparagraph (b)



-URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585







Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 420



-SubTopic 10



-Section 50



-Paragraph 1



-Subparagraph (b)



-URI http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869







Reference 3: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 420



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SAB TOPIC 5.P.4(b))



-URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140904-122747







Reference 4: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 420



-SubTopic 10



-Section S99



-Paragraph 1



-Subparagraph (SAB TOPIC 5.P.3)



-URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140864-122747







Reference 5: http://www.xbrl.org/2003/role/presentationRef



-Publisher SEC



-Name Staff Accounting Bulletin (SAB)



-Number Topic 5



-Section P



-Subsection 3, 4

+ Details

Name:	us-gaap_BusinessExitCosts1
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Revenue earned during the period arising from products sold or services provided under the terms of a contract, not elsewhere specified in the taxonomy. May include government contracts, construction contracts, and any other contract related to a particular project or product.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.1)



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

+ Details

Name:	us-gaap_ContractsRevenue
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Definition

Total costs of sales and operating expenses for the period.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03)



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

+ Details

Name:	us-gaap_CostsAndExpenses
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Details

Name:	us-gaap_CostsAndExpensesAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

+ References

No definition available.

+ Details

Name:	us-gaap_EarningsPerShareBasicAndDiluted
Namespace Prefix:	us-gaap_
Data Type:	num:perShareItemType
Balance Type:	na
Period Type:	duration

X

- Definition

The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.4)



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

+ Details

Name:	us-gaap_GeneralAndAdministrativeExpense
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Amount of the cost of borrowed funds accounted for as interest expense.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 835



-SubTopic 20



-Section 50



-Paragraph 1



-URI http://asc.fasb.org/extlink&oid=6450988&loc=d3e26243-108391







Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 942



-SubTopic 225



-Section S99



-Paragraph 1



-Subparagraph (SX 210.9-04.9)



-URI http://asc.fasb.org/extlink&oid=6879574&loc=d3e536633-122882







Reference 3: http://www.xbrl.org/2003/role/presentationRef



-Publisher SEC



-Name Regulation S-X (SX)



-Number 210



-Section 04



-Paragraph 9



-Article 9

+ Details

Name:	us-gaap_InterestExpense
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Amount before accretion (amortization) of purchase discount (premium) of interest income on nonoperating securities.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher SEC



-Name Regulation S-X (SX)



-Number 210



-Section 03



-Paragraph 7



-Article 5







Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.7(b))



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

+ Details

Name:	us-gaap_InvestmentIncomeInterest
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Definition

Revenue from multiple-deliverable arrangements that include licensing fees and services revenue. Licensing revenue is consideration received from another party for the right to use, but not own, certain of the entity's intangible assets. Licensing arrangements include, but are not limited to, rights to use a patent, copyright, technology, manufacturing process, software or trademark. Licensing fees are generally, but not always, fixed as to amount and not dependent upon the revenue generated by the licensing party. An entity may receive licensing fees for licenses that also generate royalty payments to the entity. Services revenue may be derived by providing other, nonspecified, services during the reporting period.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher SEC



-Name Regulation S-X (SX)



-Number 210



-Section 03



-Paragraph 1



-Article 5







Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.1(d),(e))



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

+ Details

Name:	us-gaap_LicenseAndServicesRevenue
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 230



-SubTopic 10



-Section 45



-Paragraph 28



-URI http://asc.fasb.org/extlink&oid=31042434&loc=d3e3602-108585







Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 260



-SubTopic 10



-Section 50



-Paragraph 1



-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257







Reference 3: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Glossary Other Comprehensive Income



-URI http://asc.fasb.org/extlink&oid=6519514







Reference 4: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Glossary Net Income



-URI http://asc.fasb.org/extlink&oid=6518256







Reference 5: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 944



-SubTopic 225



-Section S99



-Paragraph 1



-Subparagraph (SX 210.7-04.19)



-URI http://asc.fasb.org/extlink&oid=6879464&loc=d3e573970-122913







Reference 6: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.18)



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688







Reference 7: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 944



-SubTopic 225



-Section S99



-Paragraph 1



-Subparagraph (SX 210.7-04.22)



-URI http://asc.fasb.org/extlink&oid=6879464&loc=d3e573970-122913







Reference 8: http://www.xbrl.org/2003/role/presentationRef



-Publisher SEC



-Name Regulation S-X (SX)



-Number 210



-Section 03



-Paragraph 19



-Article 5







Reference 9: http://www.xbrl.org/2003/role/presentationRef



-Publisher SEC



-Name Regulation S-X (SX)



-Number 210



-Section 04



-Paragraph 20



-Article 9

+ Details

Name:	us-gaap_NetIncomeLoss
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Definition

Net income after adjustments for dividends on preferred stock (declared in the period) and/or cumulative preferred stock (accumulated for the period).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 260



-SubTopic 10



-Section 45



-Paragraph 11



-URI http://asc.fasb.org/extlink&oid=7655603&loc=d3e1377-109256

+ Details

Name:	us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Definition

The net result for the period of deducting operating expenses from operating revenues.

+ References

No definition available.

+ Details

Name:	us-gaap_OperatingIncomeLoss
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Definition

The net amount of other income and expense amounts, the components of which are not separately disclosed on the income statement, resulting from ancillary business-related activities (that is, excluding major activities considered part of the normal operations of the business) also known as other nonoperating income (expense) recognized for the period. Such amounts may include: (a) dividends, (b) interest on securities, (c) net gains or losses on securities, (d) unusual costs, (e) gains or losses on foreign exchange transactions, and (f) miscellaneous other income and expense items.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher SEC



-Name Regulation S-X (SX)



-Number 210



-Section 03



-Paragraph 9



-Article 5







Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.9)



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

+ Details

Name:	us-gaap_OtherNonoperatingIncomeExpense
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Details

Name:	us-gaap_OtherNonoperatingIncomeExpenseAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

The amount of preferred stock dividends that is an adjustment to net income apportioned to common stockholders.

+ References

No definition available.

+ Details

Name:	us-gaap_PreferredStockDividendsIncomeStatementImpact
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 985



-SubTopic 20



-Section 50



-Paragraph 1



-URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756







Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 730



-SubTopic 10



-Section 50



-Paragraph 1



-URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373

+ Details

Name:	us-gaap_ResearchAndDevelopmentExpense
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration

X

- Definition

Revenue earned during the period from non-repayable sum of money awarded to an entity to carry out a specific purpose as provided in grant agreements.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.1(e))



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

+ Details

Name:	us-gaap_RevenueFromGrants
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Definition

Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef



-Publisher FASB



-Name Accounting Standards Codification



-Topic 225



-SubTopic 10



-Section S99



-Paragraph 2



-Subparagraph (SX 210.5-03.1)



-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688







Reference 2: http://www.xbrl.org/2003/role/presentationRef



-Publisher SEC



-Name Regulation S-X (SX)



-Number 210



-Section 03



-Paragraph 1



-Article 5

+ Details

Name:	us-gaap_Revenues
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Details

Name:	us-gaap_RevenuesAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

+ References

No definition available.

+ Details

Name:	us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted
Namespace Prefix:	us-gaap_
Data Type:	xbrli:sharesItemType
Balance Type:	na
Period Type:	duration