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Summary of Revenue Recognized under Various Agreements (Detail) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2015
Dec. 31, 2014
Jun. 30, 2014
Mar. 31, 2014
Jun. 30, 2015
Jun. 30, 2014
Dec. 31, 2011
Product Information [Line Items]              
Performance of research activities   $ 8,000   $ 5,400     $ 3,000
Total revenues $ 1,550   $ 3,048   $ 2,177 $ 6,546  
Grant revenue 101   1,007   249 2,132  
National Institute of Allergy and Infectious Diseases              
Product Information [Line Items]              
Grant revenue     965     1,839  
National Institutes of Health              
Product Information [Line Items]              
Grant revenue 101   42   249 293  
Astra Zeneca              
Product Information [Line Items]              
Initial payment 63   180   126 360  
Subsequent payment 237   675   474 1,350  
Performance of research activities 630   545   801 1,432  
Total revenues $ 930   $ 1,400   $ 1,401 $ 3,142