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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Operating activities    
Net loss $ (49,808) $ (38,617)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 634 680
Gain on disposal of property and equipment   (24)
Accretion of discounts and amortization of premiums on marketable securities 314 500
Unoccupied facility expense   255
Accretion of debt discount related to debt financing (100)  
Accretion of end of term payment related to debt financing 107  
Cash-settled portion of stock-based compensation expense 387  
Stock compensation expense 3,872 2,946
Changes in operating assets and liabilities:    
Accounts receivable 70 335
Prepaid expenses and other current assets 200 (3,603)
Restricted cash and other assets   (579)
Accounts payable 648 112
Accrued liabilities and other long term liabilities (2,634) 3,217
Deferred revenues (1,401) 996
Net cash used in operating activities (47,711) (33,782)
Investing activities    
Purchases of marketable securities (18,654) (37,251)
Proceeds from maturities of marketable securities 34,585 65,794
Purchases of property and equipment, net (1,668) (919)
Net cash provided by investing activities 14,263 27,624
Financing activities    
Proceeds from issuance of common stock, net 20,213  
Proceeds from exercise of stock options and restricted stock awards 109 13
Proceeds from exercise of warrants 228  
Proceeds from Employee Stock Purchase Plan 103 70
Net cash provided by financing activities 20,653 83
Effect of exchange rate changes on cash and cash equivalents (230) (15)
Net decrease in cash and cash equivalents (13,025) (6,090)
Cash and cash equivalents at beginning of period 49,511 23,122
Cash and cash equivalents at end of period 36,486 17,032
Non-cash investing and financing activities:    
Cash paid during the year for interest 433  
Disposal of fully depreciated property and equipment 4 664
Net change in unrealized gain on marketable securities $ (1) $ 70