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Collaborative Research and Development Agreements - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended
Jan. 31, 2014
Oct. 31, 2011
Sep. 30, 2008
Sep. 30, 2015
Dec. 31, 2014
Sep. 30, 2014
Mar. 31, 2014
Dec. 31, 2012
Sep. 30, 2015
Sep. 30, 2014
Dec. 31, 2011
Aug. 31, 2014
Sep. 30, 2013
Jun. 30, 2012
May. 31, 2012
Aug. 31, 2010
Deferred Revenue Arrangement [Line Items]                                
Revenue from milestone payment         $ 8,000,000   $ 5,400,000       $ 3,000,000          
Astra Zeneca                                
Deferred Revenue Arrangement [Line Items]                                
Collaboration Revenue   $ 3,000,000                            
Revenue from milestone payment       $ 546,000   $ 309,000     $ 1,347,000 $ 1,741,000            
Deferred revenue recognition period                     33 months          
Deferred revenue       $ 10,500,000 12,800,000       10,500,000              
National Institutes of Health                                
Deferred Revenue Arrangement [Line Items]                                
Grants receivable                       $ 200,000        
National Institutes of Health | Hepatic Fibrosis and Cirrhosis                                
Deferred Revenue Arrangement [Line Items]                                
Grants receivable                         $ 200,000      
National Institutes of Health | Autoimmune Disease                                
Deferred Revenue Arrangement [Line Items]                                
Grants receivable                           $ 600,000    
National Institutes of Health | Rheumatoid Arthritis                                
Deferred Revenue Arrangement [Line Items]                                
Grants receivable                             $ 400,000  
National Institute of Allergy and Infectious Diseases | Hepatitis B Virus                                
Deferred Revenue Arrangement [Line Items]                                
Grants receivable                               $ 1,400,000
National Institute of Allergy and Infectious Diseases | Iss Technology                                
Deferred Revenue Arrangement [Line Items]                                
Research collaboration and license agreement period     5 years                          
Grants receivable     $ 17,000,000                          
Amendment                                
Deferred Revenue Arrangement [Line Items]                                
Collaboration Revenue $ 5,400,000       $ 8,000,000     $ 6,000,000                
Amendment | Maximum                                
Deferred Revenue Arrangement [Line Items]                                
Additional revenue recognized                 $ 100,000,000