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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2015
Sep. 30, 2014
Operating activities    
Net loss $ (79,932) $ (68,436)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 958 1,016
Gain on disposal of property and equipment   (24)
Accretion of discounts and amortization of premiums on marketable securities 476 714
Unoccupied facility expense   386
Accretion of debt discount related to debt financing (115)  
Cash-settled portion of stock-based compensation expense 387  
Stock compensation expense 6,502 4,532
Loss on extinguishment of debt 1,671  
Changes in operating assets and liabilities:    
Accounts receivable (436) 900
Prepaid expenses and other current assets 1,569 (2,203)
Restricted cash and other assets (211) (575)
Accounts payable 273 3,284
Accrued liabilities and other long term liabilities 364 4,334
Deferred revenues (2,219) (799)
Net cash used in operating activities (70,713) (56,871)
Investing activities    
Purchases of marketable securities (127,918) (44,807)
Proceeds from maturities of marketable securities 82,920 99,500
Purchases of property and equipment, net (4,246) (1,207)
Net cash (used in) provided by investing activities (49,244) 53,486
Financing activities    
Proceeds from issuance of common stock, net 183,899  
Payment of debt (10,990)  
Proceeds from exercise of stock options and restricted stock awards 237 13
Proceeds from exercise of warrants 222  
Proceeds from Employee Stock Purchase Plan 291 130
Net cash provided by financing activities 173,659 143
Effect of exchange rate changes on cash and cash equivalents (182) (224)
Net increase (decrease) in cash and cash equivalents 53,520 (3,466)
Cash and cash equivalents at beginning of period 49,511 23,122
Cash and cash equivalents at end of period 103,031 19,656
Non-cash investing and financing activities:    
Cash paid during the year for interest 720  
Disposal of fully depreciated property and equipment 171 675
Net change in unrealized gain on marketable securities $ 4 $ 69