<SEC-DOCUMENT>0001144204-15-010181.txt : 20150218
<SEC-HEADER>0001144204-15-010181.hdr.sgml : 20150216
<ACCEPTANCE-DATETIME>20150217162900
ACCESSION NUMBER:		0001144204-15-010181
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20150217
DATE AS OF CHANGE:		20150217
GROUP MEMBERS:		PETER KOLCHINSKY
GROUP MEMBERS:		RA CAPITAL HEALTHCARE FUND, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			DYNAVAX TECHNOLOGIES CORP
		CENTRAL INDEX KEY:			0001029142
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330728374
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-80035
		FILM NUMBER:		15623099

	BUSINESS ADDRESS:	
		STREET 1:		2929 SEVENTH STREET
		STREET 2:		SUITE 100
		CITY:			BERKELEY
		STATE:			CA
		ZIP:			94710
		BUSINESS PHONE:		5108485100

	MAIL ADDRESS:	
		STREET 1:		2929 SEVENTH STREET
		STREET 2:		SUITE 100
		CITY:			BERKELEY
		STATE:			CA
		ZIP:			94710

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RA CAPITAL MANAGEMENT, LLC
		CENTRAL INDEX KEY:			0001346824
		IRS NUMBER:				830406777
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-778-2500

	MAIL ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>v401867_sc13ga.htm
<DESCRIPTION>SC 13G/A
<TEXT>
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<P STYLE="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</P>

<P STYLE="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE 13G</B></P>

<P STYLE="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">Under the Securities Exchange Act
of 1934</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 0in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 0in"><B>(Amendment No.
2)*</B></P>

<P STYLE="font: bold 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 100%; border-bottom: Black 1pt solid; line-height: 12pt; font-size: 10pt; text-align: center; font-weight: bold"><FONT STYLE="font-size: 10pt">Dynavax
    Technologies Corporation</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(Name of Issuer)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt; font-size: 10pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid; line-height: 12pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Common
    Stock, $0.001 par value </B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(Title of Class of Securities)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt; font-size: 10pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid; line-height: 12pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>268158201</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(CUSIP Number)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt; font-size: 10pt; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: Black 1pt solid; line-height: 12pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>December
    31, 2014</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt; font-size: 10pt; text-align: center"><FONT STYLE="font-size: 10pt">(Date of Event Which Requires
    Filing of this Statement)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Check the appropriate box to designate the rule pursuant
to which this Schedule is filed:</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<TD STYLE="width: 0.25in; text-align: right"><FONT STYLE="font-family: Wingdings">&uml;</FONT></TD><TD STYLE="width: 0.25in"></TD><TD STYLE="text-align: justify">Rule 13d-1(b)</TD>
</TR></TABLE>

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<TD STYLE="width: 0.25in; text-align: right"><FONT STYLE="font-family: Wingdings">x</FONT></TD><TD STYLE="width: 0.25in"></TD><TD STYLE="text-align: justify">Rule 13d-1(c)</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0.25in; text-align: right"><FONT STYLE="font-family: Wingdings">&uml;</FONT></TD><TD STYLE="width: 0.25in"></TD><TD STYLE="text-align: justify">Rule 13d-1(d)</TD>
</TR></TABLE>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">*The remainder of this cover page shall be filled out for
a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent
amendment containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">The information required in the remainder of this cover
page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&ldquo;<B><I>Act</I></B>&rdquo;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>


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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">CUSIP No. <B>268158201</B></FONT></TD>
    <TD STYLE="line-height: 12pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>13G</B></FONT></TD>
    <TD STYLE="line-height: 12pt">Page <U> <B>&nbsp;&nbsp;&nbsp;2</B> &nbsp;&nbsp;&nbsp;</U> of <U> &nbsp;&nbsp;&nbsp;<B>7&nbsp;&nbsp;&nbsp;</B> </U> Pages</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">1.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Names of Reporting Persons.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">I.R.S. Identification Nos. of above persons (entities
    only).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt"><B>&nbsp;&nbsp;&nbsp;&nbsp;RA Capital Management,
    LLC</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">2. </FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See
    Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">SEC Use Only </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>Massachusetts</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="10" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Number of</FONT><BR>
    <FONT STYLE="font-size: 10pt">Shares</FONT><BR>
    <FONT STYLE="font-size: 10pt">Beneficially</FONT><BR>
    <FONT STYLE="font-size: 10pt">Owned by</FONT><BR>
    <FONT STYLE="font-size: 10pt">Each&nbsp;Reporting</FONT><BR>
    <FONT STYLE="font-size: 10pt">Person With</FONT></TD>
    <TD STYLE="vertical-align: top; line-height: 12pt"><FONT STYLE="font-size: 10pt">5.</FONT></TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; line-height: 12pt"><FONT STYLE="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>0 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>2,603,044 shares </B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>0 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp; <B>2,603,044 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Aggregate Amount Beneficially Owned by Each Reporting
        Person</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;<B>&nbsp;&nbsp;2,603,044 shares</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Check if the Aggregate Amount in Row (9) Excludes&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
        <FONT STYLE="font-family: Wingdings">&uml;</FONT></P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Certain Shares (See Instructions)</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; line-height: 12pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
    <TD COLSPAN="5" STYLE="vertical-align: top"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;&nbsp;&nbsp;<B>9.9%</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;&nbsp;&nbsp;<B>IA</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 15%">&nbsp;</TD>
    <TD STYLE="width: 32%">&nbsp;</TD>
    <TD STYLE="width: 33%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">CUSIP No. <B>268158201</B></FONT></TD>
    <TD STYLE="line-height: 12pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>13G</B></FONT></TD>
    <TD STYLE="line-height: 12pt">Page <U> <B>&nbsp;&nbsp;&nbsp;3</B> &nbsp;&nbsp;&nbsp;</U> of <U> &nbsp;&nbsp;&nbsp;<B>7&nbsp;&nbsp;&nbsp;</B> </U> Pages</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">1.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Names of Reporting Persons.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">I.R.S. Identification Nos. of above persons (entities
    only).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt">&nbsp;&nbsp;<FONT STYLE="font-size: 10pt"><B>&nbsp;&nbsp;Peter Kolchinsky</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">2. </FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See
    Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">SEC Use Only </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>United States</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="10" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Number of</FONT><BR>
    <FONT STYLE="font-size: 10pt">Shares</FONT><BR>
    <FONT STYLE="font-size: 10pt">Beneficially</FONT><BR>
    <FONT STYLE="font-size: 10pt">Owned by</FONT><BR>
    <FONT STYLE="font-size: 10pt">Each&nbsp;Reporting</FONT><BR>
    <FONT STYLE="font-size: 10pt">Person With</FONT></TD>
    <TD STYLE="vertical-align: top; line-height: 12pt"><FONT STYLE="font-size: 10pt">5.</FONT></TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; line-height: 12pt"><FONT STYLE="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>0 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>2,603,044 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>0 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>2,603,044 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Aggregate Amount Beneficially Owned by Each Reporting
        Person</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;&nbsp;&nbsp;<B>2,603,044 shares</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Check if the Aggregate Amount in Row (9) Excludes&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
        <FONT STYLE="font-family: Wingdings">&uml;</FONT></P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Certain Shares (See Instructions)</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;&nbsp;&nbsp;<B>9.9%</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;&nbsp;&nbsp;<B>IN</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 15%">&nbsp;</TD>
    <TD STYLE="width: 32%">&nbsp;</TD>
    <TD STYLE="width: 33%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">CUSIP No. <B>268158201</b></font></TD>
    <TD STYLE="line-height: 12pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>13G</B></FONT></TD>
    <TD STYLE="line-height: 12pt">Page <U> <B>&nbsp;&nbsp;&nbsp;4</B> &nbsp;&nbsp;&nbsp;</U> of <U> &nbsp;&nbsp;&nbsp;<B>7&nbsp;&nbsp;&nbsp;</B> </U> Pages</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">1.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Names of Reporting Persons.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">I.R.S. Identification Nos. of above persons (entities
    only).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt"><B>&nbsp;&nbsp;</b></FONT><FONT STYLE="font-size: 10pt"><B>&nbsp;&nbsp;RA Capital Healthcare Fund, L.P.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">2. </FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Check the Appropriate Box if a Member of a Group (See
    Instructions)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="4" STYLE="line-height: 12pt"><FONT STYLE="font: 10pt Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">SEC Use Only </FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
    <TD COLSPAN="5" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>Delaware</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR>
    <TD COLSPAN="3" ROWSPAN="10" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Number of</FONT><BR>
    <FONT STYLE="font-size: 10pt">Shares</FONT><BR>
    <FONT STYLE="font-size: 10pt">Beneficially</FONT><BR>
    <FONT STYLE="font-size: 10pt">Owned by</FONT><BR>
    <FONT STYLE="font-size: 10pt">Each&nbsp;Reporting</FONT><BR>
    <FONT STYLE="font-size: 10pt">Person With</FONT></TD>
    <TD STYLE="vertical-align: top; line-height: 12pt"><FONT STYLE="font-size: 10pt">5.</FONT></TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; line-height: 12pt"><FONT STYLE="font-size: 10pt">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>0 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>2,082,435
    shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>0 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
    <TD COLSPAN="3" STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    <B>2,082,435 shares</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Aggregate Amount Beneficially Owned by Each Reporting
        Person</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;&nbsp;&nbsp;<B>2,082,435
        shares</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Check if the Aggregate Amount in Row (9) Excludes&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
        <FONT STYLE="font-family: Wingdings">&uml;</FONT></P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Certain Shares (See Instructions)</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Percent of Class Represented by Amount in Row (9)</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;&nbsp;&nbsp;<B>7.9%</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
    <TD COLSPAN="5"><P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0">&nbsp;&nbsp;&nbsp;&nbsp;<B>PN</B></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="7" STYLE="border-bottom: Black 1pt solid; line-height: 12pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 15%">&nbsp;</TD>
    <TD STYLE="width: 32%">&nbsp;</TD>
    <TD STYLE="width: 33%">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt/12pt Times New Roman, Times, Serif; margin: 0">CUSIP No. <B>268158201</b></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>Item 1.</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">(a)&#9;&nbsp;&nbsp;
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Name of Issuer:</B> Dynavax Technologies Corporation (the &ldquo;Issuer&rdquo;).</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">(b)&#9;&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Address
of the Issuer&rsquo;s Principal Executive Offices: </B>2929 Seventh Street, Suite 100, Berkeley, CA 94710-2753.</P>



<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>Item 2.&#9;</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">(a)&#9;&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Name of Person Filing: </B>
This joint statement on Schedule 13G is being filed by Peter Kolchinsky, RA Capital Management, LLC (&ldquo;Capital&rdquo;), and
RA Capital Healthcare Fund, L.P. (the &ldquo;Fund&rdquo;). Mr. Kolchinsky, Capital and the Fund are collectively referred to herein
as the &ldquo;Reporting Persons.&rdquo;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">(b)&#9;<B>&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Address of Principal Business
Office:</B> The principal business office of the Reporting Persons is c/o RA Capital Management, LLC, 20 Park Plaza, Suite 1200,
Boston, MA 02116.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">(c) &#9;&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<B>Citizenship:</B> Capital is
a Massachusetts limited liability company. The Fund is a Delaware limited partnership. Mr. Kolchinsky is a United States citizen.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">(d)&#9;<B>&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Title and Class of Securities:
</B>Common stock (&ldquo;Common Stock&rdquo;).</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0in">(e)&#9;<B>&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;CUSIP
Number:</B> 268158201</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>Item 3.&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;If this statement is filed pursuant to &sect;&sect;240.13d-1(b)
or 240.13d-2(b) or (c), check whether the person filing is a:</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Not applicable.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 6pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 4.</B></TD><TD STYLE="text-align: justify"><B>Ownership:</B></TD>
</TR></TABLE>



<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Provide the following information regarding the aggregate
number and percentage of the class of securities of the issuer identified in Item 1.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(a)</TD><TD>Amount Beneficially Owned:**</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">RA Capital Management, LLC - 2,603,044 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">Peter Kolchinsky - 2,603,044 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">RA Capital Healthcare Fund, L.P. - 2,082,435 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(b)</TD><TD>Percent of Class:**</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">RA Capital Management, LLC &ndash; 9.9%</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">Peter Kolchinsky &ndash; 9.9%</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">RA Capital Healthcare Fund, L.P. &ndash; 7.9%</P>



<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>



<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;&nbsp;</P>


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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 2.7pt">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0; margin-right: 0; margin-bottom: 0">CUSIP No. <B>268158201</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 2.7pt"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 2.7pt"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 2.7pt"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-indent: -0.5in">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-indent: -0.5in"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">(c)</TD><TD>Number of shares as to which such person has:</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(i)</TD><TD>sole power to vote or to direct the vote **</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.75in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">RA Capital Management, LLC - 0 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">Peter Kolchinsky - 0 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">RA Capital Healthcare Fund, L.P. - 0 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(ii)</TD><TD>shared power to vote or to direct the vote**</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">RA Capital Management, LLC - 2,603,044 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">Peter Kolchinsky - 2,603,044 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">RA Capital Healthcare Fund, L.P. - 2,082,435 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(iii)</TD><TD>Sole power to dispose or to direct the disposition of**</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">RA Capital Management, LLC - 0 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">Peter Kolchinsky - 0 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">RA Capital Healthcare Fund, L.P. - 0 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.25in">(iv)</TD><TD>shared power to dispose or to direct the disposition of**</TD></TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">RA Capital Management, LLC - 2,603,044 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">Peter Kolchinsky - 2,603,044 shares</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">RA Capital Healthcare Fund, L.P. - 2,082,435 shares</P>



<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-indent: -0.5in"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 2.7pt">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"> ** Shares reported herein for the Reporting Persons represent shares of Common Stock issuable upon the
conversion of certain shares of Series B Convertible Preferred Stock (&ldquo;Series B Shares&rdquo;) beneficially owned as set
forth below. In the aggregate, the Reporting Persons own 43,430 Series B Shares convertible into 4,343,000 shares of Common Stock.
The Series B Shares may not be converted such that the number of shares of Common Stock held by the Reporting Persons and their
affiliates after such conversion exceeds 9.98% of the outstanding shares of Common Stock. Shares reported herein for the Fund represent
shares of Common Stock issuable upon the conversion of certain Series B Shares held of record by the Fund. Shares reported herein
for Capital represent (a) the above-referenced shares of Common Stock issuable upon the conversion of certain Series B Shares as
reported for the Fund, for which the LLC serves as the sole general partner, and (b) shares of Common Stock issuable upon the conversion
of certain Series B Shares held in such managed account. Shares reported herein for Mr. Kolchinsky represent the above-referenced
shares of Common Stock issuable upon the exercise of certain Series B Shares reported for Capital, for which Mr. Kolchinsky serves
as the manager. Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent
of its or his pecuniary interest therein.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B></B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in"><B>Item 5.</B></TD><TD><B>Ownership of Five Percent or Less of a Class:</B></TD></TR></TABLE>



<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0pt 0">Not applicable.</P>



<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><B></B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in"><B>Item 6.</B></TD><TD><B>Ownership of More than Five Percent on Behalf of Another Person:</B></TD></TR></TABLE>



<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 1in; text-indent: -1in"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Not applicable.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>


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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">CUSIP No. <B>268158201</b></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>Item 7.&#9;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Identification and Classification of the
Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Not applicable.</P>


<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 8.</B></TD><TD STYLE="text-align: justify"><B>Identification and Classification of Members of the
Group:</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Not applicable.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 9.</B></TD><TD STYLE="text-align: justify"><B>Notice of Dissolution of Group:</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Not applicable.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.75in; text-align: left"><B>Item 10.</B></TD><TD STYLE="text-align: justify"><B>Certification:</B></TD>
</TR></TABLE>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">By signing below I hereby certify that, to the best of my
knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect
of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with
or as a participant in any transaction having that purpose or effect.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><U>Exhibits</U></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0 0.5in; text-indent: -0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in">1</TD><TD>Joint Filing Agreement by and among the Reporting Persons is incorporated herein by reference to Exhibit
1 to the Schedule 13G filed by the Reporting Persons with the Securities and Exchange Commission on November 5, 2013.</TD></TR></TABLE>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><I>&nbsp;</I></P>


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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><I>&nbsp;</I></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURE</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">After reasonable inquiry and to the
best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; line-height: 12pt"><FONT STYLE="font-size: 10pt; text-transform: uppercase">&nbsp;</FONT></TD>
    <TD STYLE="width: 50%; line-height: 12pt"><FONT STYLE="font-size: 10pt; text-transform: uppercase">Date: </FONT><FONT STYLE="font-size: 10pt">February
    17, 2015</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">RA CAPITAL MANAGEMENT, LLC</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; line-height: 12pt"><FONT STYLE="font-size: 10pt">By: /s/ Peter Kolchinsky</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Peter Kolchinsky</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Manager</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">PETER KOLCHINSKY</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; line-height: 12pt"><FONT STYLE="font-size: 10pt">/s/ Peter Kolchinsky</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">RA CAPITAL HEALTHCARE FUND, L.P.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">By: RA Capital Management, LLC</FONT></TD></TR>
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    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="padding-left: 27pt; line-height: 12pt"><FONT STYLE="font-size: 10pt">General Partner</FONT></TD></TR>
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    <TD STYLE="line-height: 12pt">&nbsp;</TD></TR>
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    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; line-height: 12pt"><FONT STYLE="font-size: 10pt">By: /s/ Peter Kolchinsky</FONT></TD></TR>
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    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Peter Kolchinsky</FONT></TD></TR>
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    <TD STYLE="line-height: 12pt">&nbsp;</TD>
    <TD STYLE="line-height: 12pt"><FONT STYLE="font-size: 10pt">Manager</FONT></TD></TR>
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