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v3.3.1.900

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Operating activities |  |  |
Net loss | $ (106,794) | $ (90,722) | $ (66,720)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 1,365 | 1,404 | 1,327
Loss (gain) on disposal of property and equipment | 46 | (24) | 18
Accretion of discounts and amortization of premiums of marketable securities | 660 | 881 | 923
Unoccupied facility expense |  | 386 | 926
Accretion of debt discount related to debt financing | (115) |  |
Cash-settled portion of stock-based compensation expense | 387 |  |
Stock compensation expense | 9,316 | 6,089 | 12,340
Loss on extinguishment of debt | 1,671 |  |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (667) | 900 | (622)
Prepaid expenses and other current assets | 1,631 | (2,683) | 677
Restricted cash and other assets | (211) | 277 | 176
Accounts payable | 1,246 | (523) | (657)
Accrued liabilities and other long term liabilities | 9,017 | 4,810 | (2,291)
Deferred revenues | (10,111) | 5,467 | (4,770)
Net cash used in operating activities | (92,559) | (73,738) | (58,673)
Investing activities |  |  |
Purchases of marketable securities | (208,936) | (44,807) | (192,044)
Proceeds from maturities of marketable securities | 130,110 | 137,071 | 142,321
Purchases of property and equipment, net | (6,970) | (1,667) | (1,629)
Net cash (used in) provided by investing activities | (85,796) | 90,597 | (51,352)
Financing activities |  |  |
Proceeds from issuances of common stock, net | 183,897 |  | 80,856
Proceeds from issuances of preferred stock |  |  | 44,209
Payment of debt | (10,988) |  |
Proceeds from exercise of stock options and restricted stock awards | 531 | 49 | 112
Proceeds from Employee Stock Purchase Plan | 291 | 130 | 224
Proceeds from exercise of warrants | 228 | 163 |
Proceeds from long-term debt payable to Hercules, net |  | 9,559 |
Net cash provided by financing activities | 173,959 | 9,901 | 125,401
Effect of exchange rate changes on cash and cash equivalents | (303) | (371) | 147
Net (decrease) increase in cash and cash equivalents | (4,699) | 26,389 | 15,523
Cash and cash equivalents at beginning of year | 49,511 | 23,122 | 7,599
Cash and cash equivalents at end of year | 44,812 | 49,511 | 23,122
Non-cash investing and financing activities: |  |  |
Cash paid during the year for interest | 720 |  |
Disposal of fully depreciated property and equipment | 1,436 | 841 | 86
Net change in unrealized gain (loss) on marketable securities | $ 11 | $ 32 | $ (76)

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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition Proceeds from issuance of capital stock which provides for a specific dividend that is paid to the shareholders before any dividends to common stockholders and which takes precedence over common stockholders in the event of liquidation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow from issuance of rights to purchase common shares at predetermined price (usually issued together with corporate debt). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=49167202&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash outflow during the period from the repayment of aggregate short-term and long-term debt. Excludes payment of capital lease obligations. + References No definition available. + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3602-108585 + Details
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