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v3.3.1.900

Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands | Total | Common Stock | Preferred Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Beginning Balances at Dec. 31, 2012 | $ 114,826 | $ 183 |  | $ 550,729 | $ (595) | $ (435,491)
Beginning Balances (in shares) at Dec. 31, 2012 |  | 18,279 |  |  |  |
Issuance of common stock upon exercise of stock options and restricted stock awards | 112 |  |  | 112 |  |
Issuance of common stock upon exercise of stock options and restricted stock awards (In Shares) |  | 11 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 224 |  |  | 224 |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  | 13 |  |  |  |
Restricted Stock Award Delivered (in shares) |  | 12 |  |  |  |
Issuance of common stock, net of issuance costs | 80,999 | $ 80 |  | 80,919 |  |
Issuance of common stock, net of issuance costs (in shares) |  | 7,957 |  |  |  |
Issuance of Series B convertible preferred stock, net of issuance costs | 44,209 |  |  | 44,209 |  |
Issuance of Series B convertible preferred stock, net of issuance costs (in shares) |  |  | 43 |  |  |
Initial expenses related to ATM agreement | (143) |  |  | (143) |  |
Warrants exercised (in shares) |  | 8 |  |  |  |
Stock compensation expense | 12,340 |  |  | 12,340 |  |
Total other comprehensive income (loss) | 447 |  |  |  | 447 |
Net loss | (66,720) |  |  |  |  | (66,720)
Ending Balances at Dec. 31, 2013 | 186,294 | $ 263 |  | 688,390 | (148) | (502,211)
Ending Balances (in shares) at Dec. 31, 2013 |  | 26,280 | 43 |  |  |
Issuance of common stock upon exercise of stock options and restricted stock awards | 49 |  |  | 49 |  |
Issuance of common stock upon exercise of stock options and restricted stock awards (In Shares) |  | 5 |  |  |  |
Reverse stock split |  | $ (237) |  | 237 |  |
Issuance of common stock under Employee Stock Purchase Plan | 130 |  |  | 130 |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  | 11 |  |  |  |
Warrants exercised | 163 |  |  | 163 |  |
Warrants exercised (in shares) |  | 11 |  |  |  |
Stock compensation expense | 6,089 |  |  | 6,089 |  |
Total other comprehensive income (loss) | (1,521) |  |  |  | (1,521) |
Net loss | (90,722) |  |  |  |  | (90,722)
Ending Balances at Dec. 31, 2014 | 100,482 | $ 26 |  | 695,058 | (1,669) | (592,933)
Ending Balances (in shares) at Dec. 31, 2014 |  | 26,307 | 43 |  |  |
Issuance of common stock upon exercise of stock options and restricted stock awards | 531 |  |  | 531 |  |
Issuance of common stock upon exercise of stock options and restricted stock awards (In Shares) |  | 37 |  |  |  |
Issuance of common stock under Employee Stock Purchase Plan | 291 |  |  | 291 |  |
Issuance of common stock under Employee Stock Purchase Plan (in shares) |  | 23 |  |  |  |
Issuance of common stock, net of issuance costs | 183,897 | $ 7 |  | 183,890 |  |
Issuance of common stock, net of issuance costs (in shares) |  | 7,353 |  |  |  |
Issuance of Series B convertible preferred stock, net of issuance costs | 2 | $ 5 |  | (3) |  |
Issuance of Series B convertible preferred stock, net of issuance costs (in shares) |  | 4,343 | (43) |  |  |
Warrants exercised | 228 |  |  | 228 |  |
Warrants exercised (in shares) |  | 383 |  |  |  |
Stock compensation expense | 9,703 |  |  | 9,703 |  |
Total other comprehensive income (loss) | (1,261) |  |  |  | (1,261) |
Net loss | (106,794) |  |  |  |  | (106,794)
Ending Balances at Dec. 31, 2015 | $ 187,079 | $ 38 |  | $ 889,698 | $ (2,930) | $ (699,727)
Ending Balances (in shares) at Dec. 31, 2015 |  | 38,446 |  |  |  |

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