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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Revenues:      
Collaboration revenue $ 2,765 $ 7,933 $ 4,929
Grant revenue 683 2,688 5,138
Service and license revenue 602 411 1,184
Total revenues 4,050 11,032 11,251
Operating expenses:      
Research and development 86,943 84,580 50,870
General and administrative 22,180 17,377 25,943
Unoccupied facility expense   386 926
Total operating expenses 109,123 102,343 77,739
Loss from operations (105,073) (91,311) (66,488)
Other income (expense):      
Interest income 205 191 116
Interest expense (572) (35)  
Other income (expense), net 317 433 (348)
Loss on extinguishment of debt (1,671)    
Net loss (106,794) (90,722) (66,720)
Preferred stock deemed dividend     (8,469)
Net loss allocable to common stockholders $ (106,794) $ (90,722) $ (75,189)
Net loss per share allocable to common stockholders - basic and diluted $ (3.25) $ (3.45) $ (3.83)
Weighted average shares outstanding used to compute basic and diluted net loss per share allocable to common stockholders 32,881 26,289 19,628