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Commitments and Contingencies - Additional Information (Detail)
$ in Thousands, € in Millions
 12 Months Ended
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2013
USD ($)
Dec. 31, 2004
USD ($)
Dec. 31, 2015
EUR (€)
Dec. 31, 2014
EUR (€)
Loss Contingencies [Line Items]            
Unoccupied facility expense   $ 386 $ 926      
Rent expense, net $ 2,000 1,700 1,900      
Deferred rent 500 600        
Deferred gain (loss) on lease (500) (700)        
Cash, cash equivalents and marketable securities 196,100          
Future payments obligation $ 11,200          
Deutsche Bank Securities            
Loss Contingencies [Line Items]            
Letter of credit pledged as security | €         € 0.2  
Collateralized certificate of deposit | €         € 0.2 € 0.2
Berkeley, California (the "Berkeley Lease")            
Loss Contingencies [Line Items]            
Operating leases expiration date 2018-06          
Unoccupied facility expense   400 $ 900      
Letter of credit pledged as security       $ 400    
Collateralized certificate of deposit $ 400 $ 400        
Terms of the lease If the total amount of our cash, cash equivalents and marketable securities falls below $20 million for a period of more than 30 consecutive days during the lease term, the amount of the required security deposit will increase to $1.1 million, until such time as our projected cash and cash equivalents will exceed $20 million for the remainder of the lease term, or until our actual cash and cash equivalents remains above $20 million for a period of 12 consecutive months.          
Berkeley, California (the "Berkeley Lease") | Contingency, B            
Loss Contingencies [Line Items]            
Contingency period for cash, cash equivalents and marketable securities       12 months    
Berkeley, California (the "Berkeley Lease") | Contingency, B | Minimum            
Loss Contingencies [Line Items]            
Cash, cash equivalents and marketable securities       $ 20,000    
Berkeley, California (the "Berkeley Lease") | Contingency, A            
Loss Contingencies [Line Items]            
Increase in amount of the security deposit       $ 1,100    
Berkeley, California (the "Berkeley Lease") | Contingency, A | Minimum            
Loss Contingencies [Line Items]            
Contingency period for cash, cash equivalents and marketable securities       30 days    
Berkeley, California (the "Berkeley Lease") | Contingency, A | Maximum            
Loss Contingencies [Line Items]            
Cash, cash equivalents and marketable securities       $ 20,000    
Dusseldorf, Germany (the "Dusseldorf Lease")            
Loss Contingencies [Line Items]            
Operating leases expiration date 2023-03