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Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Common Stock
Preferred Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning Balances at Dec. 31, 2012 $ 114,826 $ 183   $ 550,729 $ (595) $ (435,491)
Beginning Balances (in shares) at Dec. 31, 2012   18,279        
Issuance of common stock upon exercise of stock options and restricted stock awards 112     112    
Issuance of common stock upon exercise of stock options and restricted stock awards (In Shares)   11        
Issuance of common stock under Employee Stock Purchase Plan 224     224    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   13        
Restricted Stock Award Delivered (in shares)   12        
Issuance of common stock, net of issuance costs 80,999 $ 80   80,919    
Issuance of common stock, net of issuance costs (in shares)   7,957        
Issuance of Series B convertible preferred stock, net of issuance costs 44,209     44,209    
Issuance of Series B convertible preferred stock, net of issuance costs (in shares)     43      
Initial expenses related to ATM agreement (143)     (143)    
Warrants exercised (in shares)   8        
Stock compensation expense 12,340     12,340    
Total other comprehensive income (loss) 447       447  
Net loss (66,720)         (66,720)
Ending Balances at Dec. 31, 2013 186,294 $ 263   688,390 (148) (502,211)
Ending Balances (in shares) at Dec. 31, 2013   26,280 43      
Issuance of common stock upon exercise of stock options and restricted stock awards 49     49    
Issuance of common stock upon exercise of stock options and restricted stock awards (In Shares)   5        
Reverse stock split   $ (237)   237    
Issuance of common stock under Employee Stock Purchase Plan 130     130    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   11        
Warrants exercised 163     163    
Warrants exercised (in shares)   11        
Stock compensation expense 6,089     6,089    
Total other comprehensive income (loss) (1,521)       (1,521)  
Net loss (90,722)         (90,722)
Ending Balances at Dec. 31, 2014 100,482 $ 26   695,058 (1,669) (592,933)
Ending Balances (in shares) at Dec. 31, 2014   26,307 43      
Issuance of common stock upon exercise of stock options and restricted stock awards 531     531    
Issuance of common stock upon exercise of stock options and restricted stock awards (In Shares)   37        
Issuance of common stock under Employee Stock Purchase Plan 291     291    
Issuance of common stock under Employee Stock Purchase Plan (in shares)   23        
Issuance of common stock, net of issuance costs 183,897 $ 7   183,890    
Issuance of common stock, net of issuance costs (in shares)   7,353        
Issuance of Series B convertible preferred stock, net of issuance costs 2 $ 5   (3)    
Issuance of Series B convertible preferred stock, net of issuance costs (in shares)   4,343 (43)      
Warrants exercised 228     228    
Warrants exercised (in shares)   383        
Stock compensation expense 9,703     9,703    
Total other comprehensive income (loss) (1,261)       (1,261)  
Net loss (106,794)         (106,794)
Ending Balances at Dec. 31, 2015 $ 187,079 $ 38   $ 889,698 $ (2,930) $ (699,727)
Ending Balances (in shares) at Dec. 31, 2015   38,446