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Difference between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate (Detail) - USD ($)
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Income Tax Disclosure [Abstract]      
Income tax benefit at federal statutory rate $ (36,301,000) $ (30,818,000) $ (22,678,000)
State tax (394,000) 1,204,000 (178,000)
Business credits (2,622,000) (1,484,000) (2,515,000)
Deferred compensation charges 1,481,000 2,710,000 3,072,000
Change in valuation allowance 36,766,000 28,093,000 22,354,000
Other 1,070,000 295,000 (55,000)
Total income tax expense $ 0 $ 0 $ 0