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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating activities      
Net loss $ (106,794) $ (90,722) $ (66,720)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 1,365 1,404 1,327
Loss (gain) on disposal of property and equipment 46 (24) 18
Accretion of discounts and amortization of premiums of marketable securities 660 881 923
Unoccupied facility expense   386 926
Accretion of debt discount related to debt financing (115)    
Cash-settled portion of stock-based compensation expense 387    
Stock compensation expense 9,316 6,089 12,340
Loss on extinguishment of debt 1,671    
Changes in operating assets and liabilities:      
Accounts receivable (667) 900 (622)
Prepaid expenses and other current assets 1,631 (2,683) 677
Restricted cash and other assets (211) 277 176
Accounts payable 1,246 (523) (657)
Accrued liabilities and other long term liabilities 9,017 4,810 (2,291)
Deferred revenues (10,111) 5,467 (4,770)
Net cash used in operating activities (92,559) (73,738) (58,673)
Investing activities      
Purchases of marketable securities (208,936) (44,807) (192,044)
Proceeds from maturities of marketable securities 130,110 137,071 142,321
Purchases of property and equipment, net (6,970) (1,667) (1,629)
Net cash (used in) provided by investing activities (85,796) 90,597 (51,352)
Financing activities      
Proceeds from issuances of common stock, net 183,897   80,856
Proceeds from issuances of preferred stock     44,209
Payment of debt (10,988)    
Proceeds from exercise of stock options and restricted stock awards 531 49 112
Proceeds from Employee Stock Purchase Plan 291 130 224
Proceeds from exercise of warrants 228 163  
Proceeds from long-term debt payable to Hercules, net   9,559  
Net cash provided by financing activities 173,959 9,901 125,401
Effect of exchange rate changes on cash and cash equivalents (303) (371) 147
Net (decrease) increase in cash and cash equivalents (4,699) 26,389 15,523
Cash and cash equivalents at beginning of year 49,511 23,122 7,599
Cash and cash equivalents at end of year 44,812 49,511 23,122
Non-cash investing and financing activities:      
Cash paid during the year for interest 720    
Disposal of fully depreciated property and equipment 1,436 841 86
Net change in unrealized gain (loss) on marketable securities $ 11 $ 32 $ (76)