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Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 210
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.5-02.20)
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Amount of deferred revenue as of balance sheet date. Deferred revenue represents collections of cash or other assets related to a revenue producing activity for which revenue has not yet been recognized. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 605
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SAB TOPIC 13.A.4(a).Q1 Response)
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-Publisher SEC
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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

No definition available.

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Amount of previously reported deferred or unearned revenue that was recognized as revenue during the period. Deferred revenue is a liability related to a revenue producing activity for which revenue has not yet been recognized. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-URI http://asc.fasb.org/extlink&oid=27012821&loc=d3e214044-122780

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Carrying amount as of the balance sheet date of amounts due under the terms of governmental, corporate, or foundation grants.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
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-Name Accounting Standards Codification
-Topic 210
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-Section S99
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Cash received from collaborators during the current period.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 25
-Subparagraph (a)
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Collaborative Research and Development Agreements - Additional Information (Detail) - USD ($)	1 Months Ended	3 Months Ended
	Oct. 31, 2011	Mar. 31, 2016	Dec. 31, 2014	Mar. 31, 2014	Dec. 31, 2012	Feb. 29, 2016	Dec. 31, 2015	Aug. 31, 2014	May. 31, 2012	Aug. 31, 2010
Deferred Revenue Arrangement [Line Items]
Accrued research and development liability		$ 6,027,000					$ 7,361,000
Accrued current liabilities		13,251,000					15,337,000
Maximum
Deferred Revenue Arrangement [Line Items]
Additional revenue recognized		100,000,000
Astra Zeneca
Deferred Revenue Arrangement [Line Items]
Collaboration Revenue	$ 3,000,000		$ 8,000,000	$ 5,400,000	$ 6,000,000
Accrued current liabilities		7,300,000
Deferred revenue		$ 1,800,000					$ 2,700,000
National Institutes of Health
Deferred Revenue Arrangement [Line Items]
Grants receivable								$ 200,000
National Institutes of Health \| Rheumatoid Arthritis
Deferred Revenue Arrangement [Line Items]
Grants receivable						$ 500,000			$ 400,000
National Institute of Allergy and Infectious Diseases \| Hepatitis B Virus
Deferred Revenue Arrangement [Line Items]
Grants receivable										$ 1,400,000