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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Operating activities    
Net loss $ (27,023) $ (26,217)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 402 335
Accretion of discounts and amortization of premiums on marketable securities 75 171
Accretion of debt discount related to debt financing   (51)
Accretion of end of term payment related to debt financing   57
Cash-settled portion of stock-based compensation expense 328  
Stock compensation expense 3,244 1,954
Changes in operating assets and liabilities:    
Accounts receivable 230 (182)
Prepaid expenses and other current assets (301) 580
Restricted cash and other assets (36)  
Accounts payable 658 2,043
Accrued liabilities and other long term liabilities (3,816) (2,357)
Deferred revenues (895) (472)
Net cash used in operating activities (27,134) (24,139)
Investing activities    
Purchases of marketable securities (61,057) (18,654)
Proceeds from maturities of marketable securities 84,420 8,750
Purchases of property and equipment, net (2,611) (618)
Net cash provided by (used in) investing activities 20,752 (10,522)
Financing activities    
Proceeds from exercise of stock options and restricted stock awards 75 10
Proceeds from exercise of warrants   26
Proceeds from Employee Stock Purchase Plan 261 103
Net cash provided by financing activities 336 139
Effect of exchange rate changes on cash and cash equivalents 92 (276)
Net decrease in cash and cash equivalents (5,954) (34,798)
Cash and cash equivalents at beginning of period 44,812 49,511
Cash and cash equivalents at end of period 38,858 14,713
Non-cash investing and financing activities:    
Cash paid during the period for interest   184
Disposal of fully depreciated property and equipment 1,154 4
Net change in unrealized gain on marketable securities $ 109 $ 8