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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Operating activities    
Net loss $ (56,009) $ (49,808)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 946 634
Accretion of discounts and amortization of premiums on marketable securities 123 314
Accretion of debt discount related to debt financing   (100)
Accretion of end of term payment related to debt financing   107
Cash-settled portion of stock-based compensation expense 602 387
Stock compensation expense 6,368 3,872
Changes in operating assets and liabilities:    
Accounts and other receivables (470) 70
Prepaid expenses and other current assets 204 200
Restricted cash and other assets (115)  
Accounts payable 1,604 648
Accrued liabilities and other long term liabilities (3,160) (2,634)
Deferred revenues (2,654) (1,401)
Net cash used in operating activities (52,561) (47,711)
Investing activities    
Purchases of marketable securities (98,108) (18,654)
Proceeds from maturities of marketable securities 135,170 34,585
Purchases of property and equipment, net (4,916) (1,668)
Net cash provided by investing activities 32,146 14,263
Financing activities    
Proceeds from issuance of common stock, net   20,213
Proceeds from exercise of stock options and restricted stock awards 99 109
Proceeds from exercise of warrants   228
Proceeds from Employee Stock Purchase Plan 261 103
Net cash provided by financing activities 360 20,653
Effect of exchange rate changes on cash and cash equivalents 30 (230)
Net decrease in cash and cash equivalents (20,025) (13,025)
Cash and cash equivalents at beginning of period 44,812 49,511
Cash and cash equivalents at end of period 24,787 36,486
Supplemental disclosure of cash flow information    
Cash paid during the period for interest   433
Accrual for litigation settlement and insurance recovery 4,050  
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment 1,158 4
Net change in unrealized gain on marketable securities $ 68 $ (1)