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v3.6.0.2

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating activities |  |  |
Net loss | $ (112,444,000) | $ (106,794,000) | $ (90,722,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 2,257,000 | 1,365,000 | 1,404,000
Write-off of assets in progress | 862,000 |  |
Loss (gain) on disposal of property and equipment | 91,000 | 46,000 | (24,000)
Accretion of discounts and amortization of premiums on marketable securities | 178,000 | 660,000 | 881,000
Unoccupied facility expense |  |  | 386,000
Accretion of debt discount related to debt financing |  | (115,000) |
Cash-settled portion of stock compensation expense | 602,000 | 387,000 | 0
Stock compensation expense | 14,126,000 | 9,316,000 | 6,089,000
Loss on extinguishment of debt |  | 1,671,000 |
Changes in operating assets and liabilities: |  |  |
Accounts and other receivables | 52,000 | (667,000) | 900,000
Prepaid expenses and other current assets | 560,000 | 1,631,000 | (2,683,000)
Restricted cash and other assets | (103,000) | (211,000) | 277,000
Accounts payable | 1,181,000 | 1,246,000 | (523,000)
Accrued liabilities and other long term liabilities | (11,759,000) | 9,017,000 | 4,810,000
Deferred revenues | (2,654,000) | (10,111,000) | 5,467,000
Net cash used in operating activities | (107,051,000) | (92,559,000) | (73,738,000)
Investing activities |  |  |
Purchases of marketable securities | (126,754,000) | (208,936,000) | (44,807,000)
Proceeds from maturities of marketable securities | 220,760,000 | 130,110,000 | 137,071,000
Purchases of property and equipment, net | (7,757,000) | (6,970,000) | (1,667,000)
Net cash provided by (used in) investing activities | 86,249,000 | (85,796,000) | 90,597,000
Financing activities |  |  |
Proceeds from issuances of common stock, net |  | 183,897,000 |
Payment of debt |  | (10,988,000) |
(Withholding) proceeds from exercise of stock options and restricted stock awards, net | (84,000) | 531,000 | 49,000
Proceeds from Employee Stock Purchase Plan | 615,000 | 291,000 | 130,000
Proceeds from exercise of warrants |  | 228,000 | 163,000
Proceeds from long-term debt, net |  |  | 9,559,000
Net cash provided by financing activities | 531,000 | 173,959,000 | 9,901,000
Effect of exchange rate changes on cash and cash equivalents | (252,000) | (303,000) | (371,000)
Net (decrease) increase in cash and cash equivalents | (20,523,000) | (4,699,000) | 26,389,000
Cash and cash equivalents at beginning of year | 44,812,000 | 49,511,000 | 23,122,000
Cash and cash equivalents at end of year | 24,289,000 | 44,812,000 | 49,511,000
Supplemental disclosure of cash flow information |  |  |
Cash paid during the year for interest |  | 720,000 |
Accrual for litigation settlement and insurance recovery | 4,975,000 |  |
Non-cash investing and financing activities: |  |  |
Disposal of fully depreciated property and equipment | 2,354,000 | 1,436,000 | 841,000
Net change in unrealized (loss) gain on marketable securities | (8,000) | $ 11,000 | $ 32,000
Astra Zeneca |  |  |
Supplemental disclosure of cash flow information |  |  |
Return of unused development funding to AstraZeneca AB “AstraZeneca” (Note 9) | 7,200,000 |  |
Milestone payment from AstraZeneca (Note 9) | $ 7,200,000 |  |

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- Definition Cash outflow for purchase of trading, available-for-sale securities and held-to-maturity securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow from issuance of rights to purchase common shares at predetermined price (usually issued together with corporate debt). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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