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Component of Current Accrued Liabilities and Accrued Research and Development (Detail) - USD ($) $ in Thousands | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | ---
Accrued Liabilities Abstract |  |
Payroll and related expenses | $ 3,753 | $ 5,866
Legal expenses | 275 | 202
Litigation settlements accrual (Note 7) | 4,975 |
Third party research expenses | 2,784 | 5,241
Third party development expenses | 2,002 | 2,072
Return of unused development funding to AstraZeneca (Note 9) |  | 7,345
Other accrued liabilities | 2,451 | 1,972
Total | $ 16,240 | $ 22,698

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