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v3.6.0.2

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenues: |  |  |
Collaboration revenue | $ 9,778 | $ 2,765 | $ 7,933
Grant revenue | 381 | 683 | 2,688
Service and license revenue | 884 | 602 | 411
Total revenues | 11,043 | 4,050 | 11,032
Operating expenses: |  |  |
Research and development | 84,493 | 86,943 | 84,580
General and administrative | 37,257 | 22,180 | 17,377
Unoccupied facility expense |  |  | 386
Total operating expenses | 121,750 | 109,123 | 102,343
Loss from operations | (110,707) | (105,073) | (91,311)
Other (expense) income: |  |  |
Interest income | 755 | 205 | 191
Interest expense |  | (572) | (35)
Other (expense) income, net | (2,492) | 317 | 433
Loss on extinguishment of debt |  | (1,671) |
Net loss | $ (112,444) | $ (106,794) | $ (90,722)
Basic and diluted net loss per share | $ (2.92) | $ (3.25) | $ (3.45)
Weighted average shares used to compute basic and diluted net loss per share | 38,506 | 32,881 | 26,289

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