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Subsequent Events - Additional Information (Detail) - USD ($) $ in Thousands |  | 1 Months Ended | 2 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Mar. 09, 2017 | Jan. 31, 2017 | Jul. 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015
Subsequent Event [Line Items] |  |  |  |  |
Proceeds from issuances of common stock, net |  |  |  |  | $ 183,897
Subsequent Event |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Percentage of reduction in global workforce |  | 38.00% |  |  |
Subsequent Event | One-time Termination Benefits |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Estimated amount of restructuring costs |  | $ 3,000 |  |  |
Cowen |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Proceeds from issuances of common stock, net |  |  | $ 49,000 |  |
Issuance of common stock, net of issuance costs (in shares) |  |  | 2,125,439 | 0 |
Cowen | Subsequent Event |  |  |  |  |
Subsequent Event [Line Items] |  |  |  |  |
Proceeds from issuances of common stock, net | $ 23,300 |  |  |  |
Issuance of common stock, net of issuance costs (in shares) | 5,650,322,000 |  |  |  |

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- Definition Detail information of subsequent event by type. User is expected to use existing line items from elsewhere in the taxonomy as the primary line items for this disclosure, which is further associated with dimension and member elements pertaining to a subsequent event. + References No definition available. + Details
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