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Equity Plans and Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2016

Share Based Compensation [Abstract]

Option Activity under Stock-Based Compensation Plans

Activity under our stock plans is set forth below:

		Shares Underlying  Outstanding Options (in thousands)				Weighted-Average Exercise Price Per Share				Weighted-Average Remaining Contractual Term (years)				Aggregate Intrinsic Value (in thousands)
Balance at December 31, 2015			2,891			$	23.34
Options granted			1,414				19.56
Options exercised			(16	)			13.81
Options cancelled:
Options forfeited (unvested)			(84	)			18.23
Options cancelled (vested)			(230	)			36.64
Balance at December 31, 2016			3,975				21.38				6.68			$	-
Vested and expected to vest at December 31, 2016			3,951				21.40				6.67			$	-
Exercisable at December 31, 2016			1,836				23.94				5.73			$	-

Summary of Restricted Stock Units Activity

Our non-vested stock awards are comprised of restricted stock units granted with performance and time-based vesting criteria. A summary of the status of non-vested restricted stock units as of December 31, 2016, and activities during 2016 are summarized as follows:  

	Number of Shares (In thousands)				Weighted-Average Grant-Date Fair Value
Non-vested as of December 31, 2015		195			$	17.52
Granted		856			$	12.42
Vested		(139	)		$	7.24
Forfeited or expired		(213	)		$	21.46
Non-vested as of December 31, 2016		699			$	12.12

Fair Value-Based Measurements and Weighted-Average Assumptions

The fair value of each option is estimated on the date of grant using the Black-Scholes option valuation model and the following weighted-average assumptions:

		Stock Options												Employee Stock Purchase Plan
		Year Ended December 31,												Year Ended December 31,
		2016				2015				2014				2016				2015				2014
Weighted-average fair value		$	9.54			$	13.37			$	15.16			$	7.86			$	9.18			$	7.45
Risk-free interest rate			1.4	%			1.7	%			1.8	%			0.6	%			0.4	%			0.2	%
Expected life (in years)			4.9				5.9				5.9				1.2				1.2				1.2
Expected Volatility			0.7				0.7				1.4				0.6				0.6				0.9

Stock-Based Compensation Expense

We recognized the following amounts of stock-based compensation expense (in thousands):

		Year Ended December 31,
		2016				2015				2014
Employees and directors stock-based compensation expense		$	14,126			$	9,316			$	6,062
Non-employees stock-based compensation expense			-				-				27
Total		$	14,126			$	9,316			$	6,089
		Year Ended December 31,
		2016				2015				2014
Research and development		$	6,742			$	4,123			$	2,868
General and administrative		$	7,384				5,193				3,221
Total		$	14,126			$	9,316			$	6,089

X

- Definition

Tabular disclosure of the amount of total share-based compensation cost, including the amounts attributable to each share-based compensation plan and any related tax benefits.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Tabular disclosure of the following for fully vested share options (or share units) and share options expected to vest at the date of the latest statement of financial position: the number, weighted-average exercise price (or conversion ratio), aggregate intrinsic value (except for nonpublic entities), and weighted-average remaining contractual term of options (or share units) outstanding.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (e)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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X

- Definition

Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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