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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues:      
Collaboration revenue $ 9,778 $ 2,765 $ 7,933
Grant revenue 381 683 2,688
Service and license revenue 884 602 411
Total revenues 11,043 4,050 11,032
Operating expenses:      
Research and development 84,493 86,943 84,580
General and administrative 37,257 22,180 17,377
Unoccupied facility expense     386
Total operating expenses 121,750 109,123 102,343
Loss from operations (110,707) (105,073) (91,311)
Other (expense) income:      
Interest income 755 205 191
Interest expense   (572) (35)
Other (expense) income, net (2,492) 317 433
Loss on extinguishment of debt   (1,671)  
Net loss $ (112,444) $ (106,794) $ (90,722)
Basic and diluted net loss per share $ (2.92) $ (3.25) $ (3.45)
Weighted average shares used to compute basic and diluted net loss per share 38,506 32,881 26,289