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Commitments and Contingencies - Additional Information (Detail)
$ in Thousands, € in Millions
 12 Months Ended
Sep. 07, 2016
USD ($)
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Dec. 31, 2004
USD ($)
Feb. 28, 2017
USD ($)
Dec. 31, 2016
EUR (€)
Dec. 31, 2015
EUR (€)
Loss Contingencies [Line Items]                
Rent expense, net   $ 2,200 $ 2,000 $ 1,700        
Deferred rent   300 500          
Accrued gain (loss) on lease   (300) (500)          
Cash, cash equivalents and marketable securities   $ 81,400            
Litigation settlement agreement date   September 7, 2016            
Estimated loss accrual on litigation   $ 4,975            
Dynavax Technologies Securities Litigation                
Loss Contingencies [Line Items]                
Litigation amount payable $ 4,100              
Dynavax Technologies Securities Litigation | Accrued Liabilities                
Loss Contingencies [Line Items]                
Estimated loss accrual on litigation 4,100              
Dynavax Technologies Securities Litigation | Prepaid Expenses and Other Current Assets                
Loss Contingencies [Line Items]                
Anticipated recovery on litigation $ 4,100              
Derivative Complaints | Accrued Liabilities | Subsequent Event                
Loss Contingencies [Line Items]                
Estimated loss accrual on litigation           $ 900    
Derivative Complaints | Prepaid Expenses and Other Current Assets | Subsequent Event                
Loss Contingencies [Line Items]                
Anticipated recovery on litigation           $ 900    
Deutsche Bank Securities                
Loss Contingencies [Line Items]                
Letter of credit pledged as security | €             € 0.2  
Collateralized certificate of deposit | €             € 0.2 € 0.2
Berkeley, California (the "Berkeley Lease")                
Loss Contingencies [Line Items]                
Operating leases expiration date   2018-06            
Letter of credit pledged as security         $ 400      
Collateralized certificate of deposit   $ 400 $ 400          
Terms of the lease   If the total amount of our cash, cash equivalents and marketable securities falls below $20 million for a period of more than 30 consecutive days during the lease term, the amount of the required security deposit will increase to $1.1 million, until such time as our projected cash and cash equivalents will exceed $20 million for the remainder of the lease term, or until our actual cash and cash equivalents remains above $20 million for a period of 12 consecutive months.            
Berkeley, California (the "Berkeley Lease") | Contingency, B                
Loss Contingencies [Line Items]                
Contingency period for cash, cash equivalents and marketable securities         12 months      
Berkeley, California (the "Berkeley Lease") | Contingency, B | Minimum                
Loss Contingencies [Line Items]                
Cash, cash equivalents and marketable securities         $ 20,000      
Berkeley, California (the "Berkeley Lease") | Contingency, A                
Loss Contingencies [Line Items]                
Increase in amount of the security deposit         $ 1,100      
Berkeley, California (the "Berkeley Lease") | Contingency, A | Minimum                
Loss Contingencies [Line Items]                
Contingency period for cash, cash equivalents and marketable securities         30 days      
Berkeley, California (the "Berkeley Lease") | Contingency, A | Maximum                
Loss Contingencies [Line Items]                
Cash, cash equivalents and marketable securities         $ 20,000      
Dusseldorf, Germany (the "Dusseldorf Lease")                
Loss Contingencies [Line Items]                
Operating leases expiration date   2023-03