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Summary of Revenue Recognized under Various Agreements (Detail) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Product Information [Line Items]                      
Total revenues $ 7,292 $ 162 $ 2,647 $ 942 $ 685 $ 1,188 $ 1,550 $ 627 $ 11,043 $ 4,050 $ 11,032
Astra Zeneca                      
Product Information [Line Items]                      
Initial and milestone payment                 7,722 238 681
Subsequent payment                 1,953 892 2,554
Performance of research activities $ 7,200               103 1,635 2,174
Total revenues                 $ 9,778 $ 2,765 $ 5,409