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Computation of Basic and Diluted Earnings Per Share (Detail) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Basic and diluted net loss per share (in thousands, except per share amounts):                      
Net loss $ (21,741) $ (34,694) $ (28,986) $ (27,023) $ (26,862) $ (30,124) $ (23,591) $ (26,217) $ (112,444) $ (106,794) $ (90,722)
Denominator for basic and diluted net loss per share:                      
Weighted-average common shares outstanding 38,544 38,512 38,496 38,472 38,429 36,532 29,335 27,065 38,506 32,881 26,289
Basic and diluted net loss per share $ (0.56) $ (0.90) $ (0.75) $ (0.70) $ (0.70) $ (0.82) $ (0.80) $ (0.97) $ (2.92) $ (3.25) $ (3.45)
Outstanding securities not included in diluted net loss per share calculation (in thousands):                      
Outstanding securities not included in diluted net loss per share calculation                 4,673 3,086 7,422
Series B Convertible Preferred Stock                      
Outstanding securities not included in diluted net loss per share calculation (in thousands):                      
Outstanding securities not included in diluted net loss per share calculation                     4,343
Stock Options and Stock Awards                      
Outstanding securities not included in diluted net loss per share calculation (in thousands):                      
Outstanding securities not included in diluted net loss per share calculation                 4,673 3,086 1,998
Warrant                      
Outstanding securities not included in diluted net loss per share calculation (in thousands):                      
Outstanding securities not included in diluted net loss per share calculation                     1,081