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Income Taxes - Additional Information (Detail) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Income Tax Disclosure [Line Items]      
Income tax expense $ 0 $ 0 $ 0
Increase (decrease) in valuation allowance 36,400,000 36,200,000 27,800,000
Unrecognized tax benefits 2,426,000 $ 2,426,000 $ 2,400,000
Unrecognized tax benefits would affect the effective tax rate 0    
Interest related to unrecognized tax benefits 0    
Penalties related to unrecognized tax benefits 0    
Accounting Standards Update 2016-09      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards 1,300,000    
Federal      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards $ 695,900,000    
Federal | Minimum      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards, expiration year 2018    
Federal | Maximum      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards, expiration year 2036    
Federal | Research And Development Tax Credits      
Income Tax Disclosure [Line Items]      
Tax credit carryforward amount $ 21,000,000    
Federal | Research And Development Tax Credits | Minimum      
Income Tax Disclosure [Line Items]      
Tax credit carryforward amount, expiration year 2018    
Federal | Research And Development Tax Credits | Maximum      
Income Tax Disclosure [Line Items]      
Tax credit carryforward amount, expiration year 2036    
California and Other States      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards $ 178,600,000    
California and Other States | Minimum      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards, expiration year 2017    
California and Other States | Maximum      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards, expiration year 2036    
California State | Research And Development Tax Credits      
Income Tax Disclosure [Line Items]      
Tax credit carryforward amount $ 15,900,000    
Foreign      
Income Tax Disclosure [Line Items]      
Net operating loss carryforwards $ 15,900,000