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Difference between Consolidated Income Tax Benefit and Amount Computed by Federal Statutory Income Tax Rate (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Income Tax Disclosure [Abstract]
Income tax benefit at federal statutory rate	$ (38,183,000)	$ (36,301,000)	$ (30,818,000)
State tax	(334,000)	(394,000)	1,204,000
Business credits	(1,950,000)	(2,622,000)	(1,484,000)
Deferred compensation charges	3,016,000	1,481,000	2,710,000
Change in valuation allowance	36,751,000	36,766,000	28,093,000
Other	700,000	1,070,000	295,000
Total income tax expense	$ 0	$ 0	$ 0

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

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