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Selected Quarterly Financial Data (Detail) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Quarterly Financial Information Disclosure [Abstract]                      
Revenues $ 7,292 $ 162 $ 2,647 $ 942 $ 685 $ 1,188 $ 1,550 $ 627 $ 11,043 $ 4,050 $ 11,032
Net loss $ (21,741) $ (34,694) $ (28,986) $ (27,023) $ (26,862) $ (30,124) $ (23,591) $ (26,217) $ (112,444) $ (106,794) $ (90,722)
Basic and diluted net loss per share $ (0.56) $ (0.90) $ (0.75) $ (0.70) $ (0.70) $ (0.82) $ (0.80) $ (0.97) $ (2.92) $ (3.25) $ (3.45)
Weighted average shares used to compute basic and diluted net loss per share 38,544 38,512 38,496 38,472 38,429 36,532 29,335 27,065 38,506 32,881 26,289