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Subsequent Events - Additional Information (Detail) - USD ($)
$ in Thousands
 1 Months Ended 2 Months Ended 12 Months Ended
Mar. 09, 2017
Jan. 31, 2017
Jul. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Subsequent Event [Line Items]          
Proceeds from issuances of common stock, net         $ 183,897
Subsequent Event          
Subsequent Event [Line Items]          
Percentage of reduction in global workforce   38.00%      
Subsequent Event | One-time Termination Benefits          
Subsequent Event [Line Items]          
Estimated amount of restructuring costs   $ 3,000      
Cowen          
Subsequent Event [Line Items]          
Proceeds from issuances of common stock, net     $ 49,000    
Issuance of common stock, net of issuance costs (in shares)     2,125,439 0  
Cowen | Subsequent Event          
Subsequent Event [Line Items]          
Proceeds from issuances of common stock, net $ 23,300        
Issuance of common stock, net of issuance costs (in shares) 5,650,322,000