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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Operating activities    
Net loss $ (25,287) $ (27,023)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 789 402
Gain on disposal of property and equipment (21)  
Accretion of discounts and amortization of premiums on marketable securities (10) 75
Cash-settled portion of stock-based compensation expense   328
Stock compensation expense 3,821 3,244
Changes in operating assets and liabilities:    
Accounts and other receivables (123) 230
Prepaid expenses and other current assets (39) (301)
Restricted cash and other assets (907) (36)
Accounts payable (2,110) 658
Accrued liabilities and other long term liabilities (1,363) (3,816)
Deferred revenues   (895)
Net cash used in operating activities (25,250) (27,134)
Investing activities    
Purchases of marketable securities (44,652) (61,057)
Proceeds from maturities of marketable securities 37,875 84,420
Purchases of property and equipment, net (234) (2,611)
Net cash (used in) provided by investing activities (7,011) 20,752
Financing activities    
Proceeds from issuance of common stock, net 29,535  
(Tax withholding) proceeds from exercise of stock options and restricted stock awards, net (303) 75
Proceeds from Employee Stock Purchase Plan 155 261
Net cash provided by financing activities 29,387 336
Effect of exchange rate changes on cash and cash equivalents 57 92
Net decrease in cash and cash equivalents (2,817) (5,954)
Cash and cash equivalents at beginning of period 24,289 44,812
Cash and cash equivalents at end of period 21,472 38,858
Supplemental disclosure of cash flow information    
Release of accrual for litigation settlement and insurance recovery (Note 4) 4,050  
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment   1,154
Net change in unrealized (loss) gain on marketable securities $ (29) $ 109