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Commitments and Contingencies - Additional Information (Detail) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Sep. 07, 2016
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Dec. 31, 2016
Loss Contingencies [Line Items]            
Reversal of deferred rent liability   $ 200   $ 209    
Rent expense, net   400 $ 600 1,000 $ 1,100  
Deferred rent   $ 400   $ 400   $ 300
Litigation settlement agreement date       September 7, 2016    
Dynavax Technologies Securities Litigation            
Loss Contingencies [Line Items]            
Litigation amount payable $ 4,100          
Dynavax Technologies Securities Litigation | Accrued Liabilities            
Loss Contingencies [Line Items]            
Estimated loss accrual on litigation           4,100
Dynavax Technologies Securities Litigation | Prepaid Expenses and Other Current Assets            
Loss Contingencies [Line Items]            
Anticipated recovery on litigation           4,100
Derivative Complaints | Accrued Liabilities            
Loss Contingencies [Line Items]            
Estimated loss accrual on litigation           900
Derivative Complaints | Prepaid Expenses and Other Current Assets            
Loss Contingencies [Line Items]            
Anticipated recovery on litigation           $ 900
Berkeley, California (the "Berkeley Lease")            
Loss Contingencies [Line Items]            
Operating leases expiration date       2025-12    
Dusseldorf, Germany (the "Dusseldorf Lease")            
Loss Contingencies [Line Items]            
Operating leases expiration date       2023-03