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Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
Collaboration revenue		$ 1,683		$ 2,578
Grant revenue	$ 105	88	$ 253	127
Service and license revenue		876		884
Total revenues	105	2,647	253	3,589
Operating expenses:
Research and development	14,814	22,750	31,159	42,817
General and administrative	5,612	9,151	12,084	17,320
Restructuring			2,783
Total operating expenses	20,426	31,901	46,026	60,137
Loss from operations	(20,321)	(29,254)	(45,773)	(56,548)
Other income (expense):
Interest income	235	220	380	445
Other income (expense), net	(232)	48	(212)	94
Net loss	$ (20,318)	$ (28,986)	$ (45,605)	$ (56,009)
Basic and diluted net loss per share	$ (0.41)	$ (0.75)	$ (1.00)	$ (1.46)
Weighted average shares used to compute basic and diluted net loss per share	49,700	38,496	45,787	38,491

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