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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Operating activities    
Net loss $ (45,605) $ (56,009)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 1,674 946
Gain on disposal of property and equipment (24)  
Accretion of discounts and amortization of premiums on marketable securities (35) 123
Reversal of deferred rent upon lease amendment (209)  
Cash-settled portion of stock-based compensation expense   602
Stock compensation expense 7,184 6,368
Changes in operating assets and liabilities:    
Accounts and other receivables 532 (470)
Prepaid expenses and other current assets (1,642) 204
Other assets 81 (115)
Accounts payable (2,934) 1,604
Accrued liabilities and other long term liabilities (1,664) (3,160)
Deferred revenues   (2,654)
Net cash used in operating activities (42,642) (52,561)
Investing activities    
Purchases of marketable securities (93,045) (98,108)
Proceeds from maturities of marketable securities 60,875 135,170
Purchases of property and equipment, net (242) (4,916)
Net cash (used in) provided by investing activities (32,412) 32,146
Financing activities    
Proceeds from issuance of common stock, net 88,200  
(Tax withholding) proceeds from exercise of stock options and restricted stock awards, net (303) 99
Proceeds from Employee Stock Purchase Plan 155 261
Net cash provided by financing activities 88,052 360
Effect of exchange rate changes on cash and cash equivalents 388 30
Net increase (decrease) in cash and cash equivalents 13,386 (20,025)
Cash and cash equivalents at beginning of period 24,289 44,812
Cash and cash equivalents at end of period 37,675 24,787
Supplemental disclosure of cash flow information    
Accrual for litigation settlement and insurance recovery (Note 4)   4,050
Release of accrual for litigation settlement and insurance recovery (Note 4) 4,050  
Non-cash investing and financing activities:    
Disposal of fully depreciated property and equipment   1,158
Net change in unrealized (loss) gain on marketable securities $ (45) $ 68